阿托伐他汀钙对急性脑卒中患者血清胶质纤维酸性蛋白、肿瘤坏死因子-α、神经元特异性烯醇化酶含量及神经功能变化的影响

发布时间：2018-04-09 04:16

本文选题：阿托伐他汀钙　切入点：急性脑卒中　出处：《中国老年学杂志》2016年10期

【摘要】：目的探讨阿托伐他汀钙对急性脑卒中血清胶质纤维酸性蛋白(GFAP)、肿瘤坏死因子(TNF)-α、神经元特异性烯醇化酶(NSE)含量及神经功能变化的影响。方法选取2013年9月至2014年12月该院神经内科急性缺血性脑卒中患者86例,根据随机数字表法随机分为两组:对照组43例,予非他汀类降脂药20 mg/d,一次口服;实验组43例,予以阿托伐他汀钙20 mg/d,一次口服。比较两组患者治疗前后血清GFAP、TNF-α、NSE含量及神经功能的变化。结果实验组血清GFAP、TNF-α及NSE水平明显低于对照组,美国卫生研究院卒中量表(NIHSS)评分明显低于对照组,日常生活活动能力(ADL)评分明显高于对照组,总显效率明显高于对照组,不良反应发生率高于对照组(均P0.05);两组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)水平与治疗前相比无统计学意义(P0.05)。结论阿托伐他汀钙对急性脑卒中患者具有较好的抗感染、抗氧化作用,能有效改善患者的神经功能,且安全性较高。
[Abstract]:Objective to investigate the effects of Atto vastatin calcium on the content of serum glial fibrillary acidic protein (GFAP), tumor necrosis factor TNF- 伪 and neuron-specific enolase (NSE) and the changes of nerve function in patients with acute stroke.Methods from September 2013 to December 2014, 86 patients with acute ischemic stroke were randomly divided into two groups: the control group (43 cases), the control group (43 cases), the control group (43 cases), the control group (43 cases), the control group (43 cases), the control group (43 cases), the control group (43 cases), and the control group (43 cases).Atto vastatin calcium 20 mg / d, once oral.The changes of serum GFAPP TNF- 伪 NSE and nerve function before and after treatment were compared between the two groups.Results the serum levels of GFAPN TNF- 伪 and NSE in the experimental group were significantly lower than those in the control group, and the scores of NIHSS and ADL were significantly lower in the experimental group than in the control group. The ADL score of the experimental group was significantly higher than that of the control group, and the total effective rate was significantly higher than that of the control group.The incidence of adverse reactions was higher than that of the control group (all P0.05%), and the levels of alanine aminotransferase (alt) and glutamic oxaloacetic transaminase (AST) in the two groups were not significantly different from those before treatment (P 0.05).Conclusion Atto vastatin calcium has a good anti-infective and antioxidant effect on patients with acute stroke. It can effectively improve the neurological function of patients with acute stroke and has higher safety.
【作者单位】：南方医科大学附属南方医院神经内科;
【分类号】：R743.3

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