影响rt-PA治疗急性缺血性脑卒中患者临床预后的因素分析

发布时间：2018-04-10 12:33

本文选题：重组组织型纤溶酶原激活剂 + 急性缺血性脑卒中　；参考：《福建医科大学》2013年硕士论文

【摘要】：目的探讨影响重组组织型纤溶酶原激活剂（rt-PA）静脉溶栓治疗急性缺血性脑卒中患者预后的因素。方法回顾性分析接受rt-PA静脉溶栓治疗的101例急性缺血性脑卒中患者的临床资料，按治疗后第90日改良Rankin量表(mRS)评分，分为预后良好组(mRS评分0-1分)及预后不良组(mRS评分2-6分)，比较两组患者的临床资料，采用单因素和Logistic回归分析影响预后的因素。结果预后良好组(55例)与预后不良组(46例)相比，年龄较小(P=0.029)，既往有糖尿病病史者比例较少（P=0.012），溶栓前血糖较低(P=0.012)，溶栓前收缩压较低(P=0.003)，溶栓前美国国立卫生研究院卒中量表评分(NIHSS评分)低(P=0.002)，起病到治疗时间较短(P=0.044)。Logistic回归分析表明溶栓前NIHSS评分低(OR0.885，95%CI0.793-0.989）、溶栓前血糖较低（OR0.699，95%CI0.491-0.994）、溶栓前收缩压较低（OR0.962，，95%CI0.929-0.997）、既往无糖尿病病史(OR0.968，95%CI0.941-0.996）者与溶栓预后好显著相关。结论溶栓前NIHSS评分低、溶栓前血糖较低、溶栓前收缩压较低及既往无糖尿病病史者的溶栓预后好。
[Abstract]:Objective to investigate the prognostic factors of recombinant tissue plasminogen activator rt-PA in patients with acute ischemic stroke.Methods the clinical data of 101 patients with acute ischemic stroke who received intravenous thrombolytic therapy with rt-PA were retrospectively analyzed.The patients were divided into good prognosis group (0-1 score) and poor prognosis group (2-6 scores). The clinical data of the two groups were compared. Univariate and Logistic regression analysis were used to analyze the prognostic factors.Results 55 patients with good prognosis were compared with 46 patients with poor prognosis.Conclusion NIHSS score before thrombolysis is low, blood glucose before thrombolysis is lower, systolic blood pressure before thrombolysis is lower, and the prognosis of thrombolytic patients with no history of diabetes is good.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.3

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