缺氧诱导因子1α在烧伤修复中作用的研究进展

发布时间：2018-04-11 11:00

  本文选题：烧伤 + 缺氧诱导因子-α　； 参考：《山东医药》2016年29期

【摘要】：缺氧诱导因子1α(HIF-1α)作为机体适应氧环境变化的主要转录调节因子,参与了烧伤后血管通透性改变、肠黏膜屏障破坏、细胞凋亡、血管再生、细胞迁移等病理生理过程。HIF-1α能介导碱烧伤后角膜新生血管的形成,也能促进烧伤创面的修复。HIF-1α还可通过基因治疗,改善老年烧伤创面愈合延迟的缺陷。HIF-1α的这些作用很可能成为烧伤治疗的新靶点,但烧伤创面的恶劣微环境也为其干预治疗提出了挑战。
[Abstract]:Hypoxia-inducible factor-1 伪 (HIF-1 伪), as the main transcription regulatory factor, is involved in the changes of vascular permeability, intestinal mucosal barrier, apoptosis and vascular regeneration after burn.Cell migration and other pathophysiological processes. HIF-1 伪 can mediate corneal neovascularization after alkali burn, and promote the repair of burn wound. HIF-1 伪 can also be treated by gene therapy.These effects of HIF-1 伪 on the delayed healing of senile burn wounds are likely to be new targets for burn treatment, but the poor microenvironment of burn wounds also poses a challenge to the intervention of burn wounds.
【作者单位】： 西南医科大学附属医院;
【基金】：国家自然科学基金资助项目(31271049)
【分类号】：R644
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本文编号：1735709