人舒张压与急性完全大脑中动脉闭塞患者临床转归的关系分析

发布时间：2018-04-13 20:02

  本文选题：舒张压 + 急性完全大脑中动脉闭塞　； 参考：《吉林大学》2013年硕士论文

【摘要】：目的：通过研究急性cMCAO患者的临床转归与DBP以及其他危险因素的相关性，从而为临床上急性cMCAO的治疗和预后判定提供新的证据和线索。 研究方法：本研究回顾性收集2011年1月~2012年11月在吉林大学第一临床医院神经内科收治的300例缺血性脑血管病住院患者，符合2010中国急性缺血性脑梗死诊治诊断标准，使用Excel软件收集资料。采用SPSS17.0统计学软件，根据数据资料的不同分别采用t检验、Wilcoxon秩和检验、卡方检验、Fisher精确概率检验，p0.05为具有统计学意义。同时应用二分类单因素和多因素Logistic回归分析法和线性趋势性检验。 结果：300名患者平均年龄63.91±7.23岁，男性164名。急性cMCAO患者126名（42.0%），平均年龄67.72±6.91岁，男性58名。研究结果显示：（1）年龄、性别、吸烟史、肥胖、心房纤颤和颈内动脉闭塞是急性cMCAO的相关危险因素。（2）吸烟史、入院时DBP、入院时血糖和NIHSS评分是急性cMCAO死亡的相关危险因素。（3）年龄、入院时DBP、入院时血糖及NIHSS评分是急性cMCAO住院患者死亡的主要相关危险因素。（4）入院时DBP水平在100~109mmHg急性cMCAO死亡风险最低。线性趋势性检验结果显示，，随着入院时DBP水平的增加或者减少，死亡的危险性也随之增加（p=0.029，p0.05）。 结论：（1）急性cMCAO的主要相关危险因素包括年龄、性别、吸烟史、肥胖、心房纤颤和颈内动脉闭塞等。（2）急性cMCAO不良预后的主要相关危险因素包括年龄、入院时血糖水平、吸烟史、入院时DBP及NIHSS评分等。（3）入院时DBP水平低于100mmHg或者高于110mmHg时，急性cMCAO死亡危险性明显增高。随着入院时DBP水平的增加或者减少，死亡的危险性也随之增加。
[Abstract]:Objective: to study the relationship between clinical outcome and DBP and other risk factors in patients with acute cMCAO, so as to provide new evidence and clues for clinical treatment and prognosis of acute cMCAO.Methods: from January 2011 to November 2012, 300 patients with ischemic cerebrovascular disease admitted in the Department of Neurology, the first Clinical Hospital of Jilin University, were collected retrospectively. The results were in accordance with the diagnostic criteria for acute ischemic cerebral infarction (ACI) in China in 2010 years.Collect data using Excel software.Using SPSS17.0 statistical software, t test and Wilcoxon rank sum test were used according to different data data, and Chi-square test showed that Fisher accurate probability test was statistically significant.At the same time, Logistic regression analysis and linear trend test were used.Results the average age of 300 patients was 63.91 卤7.23 years old, 164 males.There were 126 patients with acute cMCAO (mean age 67.72 卤6.91 years, male 58).The results showed that age, sex, smoking history, obesity, atrial fibrillation and internal carotid artery occlusion were the risk factors associated with acute cMCAO.DBP, blood glucose and NIHSS score were the main risk factors of death in patients with acute cMCAO on admission. (4) DBP level was the lowest in acute cMCAO at admission.The results of linear trend test showed that the risk of death increased with the increase or decrease of DBP level at admission.Conclusion the main risk factors associated with acute cMCAO include age, sex, smoking history, obesity, atrial fibrillation and internal carotid artery occlusion. The main risk factors for poor prognosis of acute cMCAO include age, blood glucose level at admission, smoking history.The risk of acute cMCAO death was significantly increased when the level of DBP was lower than 100mmHg or higher than that of 110mmHg at admission.As DBP levels increase or decrease at admission, the risk of death increases.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.3

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