柴胡注射液对接受PCI治疗的急性心肌梗死患者的临床疗效及可能机制

发布时间：2018-04-14 13:01

  本文选题：柴胡注射液 + 急性心肌梗死　； 参考：《东南大学学报(医学版)》2017年03期

【摘要】：目的:考察柴胡注射液对接受经皮冠状动脉介入(PCI)治疗的急性心肌梗死(AMI)患者的临床疗效及可能机制。方法:收集接受PCI治疗的AMI患者128例,分为观察组和对照组各64例,观察组在对照组治疗基础上给予柴胡注射液治疗。于PCI术前、术后检测超声心动、超敏C-反应蛋白(hs-CRP),B型氨基端利钠肽原(pro-BNP)、基质金属蛋白酶-9(MMP-9)、血清活性氧簇(ROS)、血管内皮生长因子(VEGF),并随访1年。结果:PCI术后,两组左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室舒张末容积(LVEDV)以及血清hs-CRP、BNP、MMP-9、ROS、VEGF水平较治疗前降低(P0.05),LVEF较治疗前增高(P0.05),呈时间依赖性升高;与对照组相比,观察组心率、LVEDV、LVEDD、LVESD及血清hs-CRP、BNP、MMP-9、ROS、VEGF水平降低(P0.05),LVEF增高(P0.05);随访1年,两组均无失访病例,观察组靶血管血运重建和总恶性事件发生较对照组少(P0.05)。结论:柴胡注射液对接受PCI治疗的AMI患者具有良好的效果,可能与改善心功能及降低氧化应激有关。
[Abstract]:Objective: to investigate the clinical effect and possible mechanism of Chaihu injection in patients with acute myocardial infarction (AMI) treated by percutaneous coronary intervention (PCI).Methods: 128 AMI patients treated with PCI were divided into two groups: observation group (n = 64) and control group (n = 64).Before and after PCI, echocardiography, hypersensitive C-reactive protein (CRP) B type amino-terminal natriuretic peptide pro-BNPN, matrix metalloproteinase-9 (MMP-9), serum reactive oxygen species (Ros) and vascular endothelial growth factor (VEGF) were detected and followed up for 1 year.Results after PCI, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDDN), left ventricular end-systolic diameter (LVESDN), left ventricular end-diastolic volume (LVEDVV) and serum hs-CRPNP-MMP-9 rosiform VEGF levels in both groups were significantly lower than those before treatment, and LVEF was increased in a time dependent manner compared with that before treatment. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEF) and left ventricular end-diastolic volume (LVEF) were increased in a time-dependent manner.Compared with the control group, the levels of HR, LVED, LVESD and serum hs-CRPNP-BNPMMP-9 / ROSS-VEGF in the observation group were significantly lower than those in the control group (P 0.05) and LVEF was higher than that in the control group (P 0.05), and there were no cases in the two groups after one year follow-up, and the incidence of target blood vessel revascularization and total malignant events in the observation group was less than that in the control group (P 0.05).Conclusion: Bupleurum injection has a good effect on AMI patients treated with PCI, which may be related to improving cardiac function and reducing oxidative stress.
【作者单位】： 即墨市人民医院急诊科;即墨市人民医院心内科;即墨市中医医院内科;
【分类号】：R542.22
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本文编号：1749400