簇集蛋白在急性脑梗死中的表达及其临床意义

发布时间：2018-04-15 05:06

  本文选题：急性脑梗死 + 簇集蛋白　； 参考：《重庆医学》2016年21期

【摘要】：目的探讨簇集蛋白(CLU)在急性脑梗死(ACI)中的表达及其临床意义。方法选取2013年5~12月于南昌大学第一附属医院住院(首次发病48h内)的ACI患者154例作为ACI组,根据神经功能缺损程度、有无斑块进行亚分组,另选取45例同期体检健康者作为对照组,检测血清CLU、补体C3水平,进行美国国立卫生院神经功能缺损评分(NIHSS)及Barthel指数评定,随访康复经过及结局至发病后90d,比较分析血清CLU水平。结果 ACI组患者血清CLU、补体C3水平均较对照组增高,差异均有统计学意义(P0.01),且ACI患者血清CLU与补体C3水平呈正相关(r=0.430,P=0.000)。有斑块、神经功能缺损程度重的患者血清CLU水平高于无斑块、神经功能缺损程度轻的患者,差异均有统计学意义(P0.01或P0.05)。除痊愈与显效患者血清CLU水平比较差异无统计学意义(P0.05),其余各预后类型患者血清CLU水平比较,差异均有统计学意义(P0.01或P0.05),血清CLU水平越低患者康复情况越好。结论 CLU在脑梗死发生后可调节补体系统发挥作用,血清CLU水平与ACI患者颈动脉斑块、神经功能缺损程度及预后均相关,可作为ACI患者病情评估及指导预后的生化指标之一。
[Abstract]:Objective to investigate the expression and clinical significance of cluster protein (CLU) in acute cerebral infarction (ACI).Methods 154 ACI patients who were hospitalized in the first affiliated Hospital of Nanchang University from May to December 2013 (within 48 hours of first onset) were selected as ACI group.In addition, 45 healthy subjects were selected as control group. Serum CLU and complement C3 levels were measured, and the neurological impairment score (NIH) and Barthel index were evaluated.The patients were followed up to 90 days after onset and the serum CLU levels were compared and analyzed.Results the levels of serum CLU and C3 in ACI group were significantly higher than those in control group (P 0.01). There was a positive correlation between serum CLU and complement C3 levels in ACI patients.The serum CLU levels in patients with plaque and severe neurological impairment were significantly higher than those without plaque and mild neurological impairment (P 0.01 or P 0.05).There was no significant difference in serum CLU level between cured patients and patients with marked effect (P 0.05), but there were significant differences in serum CLU levels between patients with different prognostic types (P 0.01 or P 0.05). The lower the serum CLU level was, the better the recovery was.Conclusion CLU can regulate the complement system after cerebral infarction. The level of serum CLU is correlated with the degree of carotid plaque, nerve function defect and prognosis in patients with ACI. It can be used as one of the biochemical indexes to evaluate and guide the prognosis of patients with ACI.
【作者单位】： 江西省宜春市人民医院干部综合病房;南昌大学第一附属医院神经内科;
【分类号】：R743.3
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本文编号：1752631