血清NSE、HCY及8-羟基脱氧鸟苷酸在急性脑梗死患者中的表达及意义

发布时间：2018-04-16 13:06

本文选题：神经元特异性烯醇化酶 + 同型半胱氨酸　；参考：《重庆医学》2017年31期

【摘要】：目的探讨血清神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)及8-羟基脱氧鸟苷酸(8-OHdG)在急性脑梗死患者中的表达及意义。方法选取该院2013年3月至2015年12月神经内科收治的100例急性脑梗死患者为脑梗死组,选择100例同期在该院健康体检者为对照组,脑梗死组再根据梗死体积将患者分为3组,梗死区大于10cm~3为大体积梗死组(L组),5~10cm~3为中体积梗死组(M组),5cm~3为小体积梗死组(S组)。比较脑梗死组与对照组,L组、M组、S组血清NSE、HCY及8-OHdG水平。采用Pearson相关检验对HCY、8-OHdG、NSE与脑梗死体积、神经功能缺损、预后情况进行相关性分析。结果观察组患者HCY、8-OHdG及NSE水平较对照组高,差异有统计学意义(P0.05),L组较M组、S组患者HCY、8-OHdG及NSE水平高,差异有统计学意义(P0.05),HCY、8-OHdG及NSE与脑梗死体积、神经功能缺损呈正相关,与预后情况呈负相关。结论血清NSE、HCY及8-OHdG在急性脑梗死患者中升高,且随着梗死体积的增大逐渐增高,血清NSE、HCY及8-OHdG可用于病情及预后评估。
[Abstract]:Objective to investigate the changes of serum neuron specific enolase (NSE), homocysteine (Hcy) and 8- hydroxydeoxyguanosine acid (8-OHdG) expression and significance in patients with acute cerebral infarction. Methods 100 cases of acute cerebral infarction in our hospital from March 2013 to December 2015 from the Department of neurology patients died of cerebral infarction group, 100 cases in the healthy control group, cerebral infarction group according to the infarction volume of patients were divided into 3 groups, the infarction area is larger than 10cm~3 for the large volume of infarction group (L group), 5~10cm~3 is the volume of infarction group (M group), 5cm~3 for the small volume infarction group (S group). The cerebral infarction group and control group, L group, M group, S group, serum NSE, HCY and 8-OHdG level. The Pearson correlation test was used for HCY, 8-OHdG, NSE and cerebral infarction volume and neurological deficit and prognosis were analyzed. Results in the observation group, HCY, 8-OHdG and NSE higher than the control group, the difference is Statistical significance (P0.05), L group and M group, S group HCY, 8-OHdG and NSE level is high, the difference was statistically significant (P0.05), HCY, 8-OHdG and NSE and cerebral infarction volume and neurological deficit were positively correlated, negatively correlated with prognosis. Conclusion the serum levels of NSE, HCY and 8-OHdG increased in acute cerebral infarction patients, and with the increasing of infarct volume increased, serum NSE, HCY and 8-OHdG can be used to assess the severity and prognosis.

【作者单位】：四川省遂宁市中心医院检验科;
【分类号】：R743.33

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