丙泊酚对脓毒症大鼠肝损伤保护作用的实验研究

发布时间：2018-04-17 20:06

本文选题：脓毒症 + 丙泊酚　；参考：《内蒙古大学》2013年硕士论文

【摘要】：丙泊酚(propofol),其化学名称为2、6-双异丙基苯酚,是当前在医疗中广泛应用于麻醉的诱导,麻醉的维持以及ICU病房的急危重患者的镇静治疗的一种新型的,快速的,短时效的全身静脉麻醉药,它在麻醉的诱导方面起效非常快,患者术后苏醒的又非常迅速,而且患者的各方面功能恢复的又比较完善,手术后患者的恶心以及呕吐的发生率又比较低。有专家研究表明：丙泊酚对肝脏能起到很好的保护作用,本研究以大鼠为研究对象,将24只大鼠随机分为3组,每组8只。正常对照组：腹腔注射与静脉泵注和其他两组等容积的生理盐水；LPS组：腹腔注射LPS10mg/kg,同时持续泵注生理盐水1ml/h；丙泊酚干预组：腹腔注射LPS10mg/kg,同时持续泵注丙泊酚生理盐水溶液Iml/h,丙泊酚的剂量为5mg/kg/h。观察点为腹腔注射LPS或生理盐水后2h和6h。结果表明,丙泊酚可以降低脓毒症大鼠血清中ALT, AST, IL-6, TNF-α的水平,同时,还可以减轻脓毒症大鼠相应的毒性症状。表明：丙泊酚对脓毒症大鼠的肝脏损伤有一定的保护作用。
[Abstract]:Propofol propofolium, whose chemical name is 2o 6- diisopropyl phenol, is a new and rapid method for the induction of anesthesia, maintenance of anesthesia and sedation of critical patients in ICU ward.A short-aged general intravenous anesthetic that works very quickly in induction of anesthesia, which resuscitates very quickly after surgery, and whose various functions have recovered fairly well.The incidence of nausea and vomiting was lower after surgery.Some expert studies have shown that propofol can protect the liver very well. In this study, 24 rats were randomly divided into 3 groups with 8 rats in each group.Normal control group: intraperitoneal injection and intravenous injection and the other two groups of the same volume of normal saline LPS group: intraperitoneal injection of LPS 10 mg / kg and continuous infusion of saline 1 ml / h; propofol intervention group: intraperitoneal injection of 10 mg / kg of propofol and continuous infusion of propofol physiologicalThe dose of propofol in saline solution is 5 mg / kg / h.The observation point was 2 h and 6 h after intraperitoneal injection of LPS or saline.The results showed that propofol could decrease the levels of alt, AST, IL-6, TNF- 伪 in serum of septic rats, and also alleviate the corresponding toxic symptoms of sepsis rats.The results showed that propofol had protective effect on liver injury in septic rats.
【学位授予单位】：内蒙古大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R614;R459.7

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