尼可地尔对急性心肌梗死的再灌注疗效的Meta分析

发布时间：2018-04-20 01:16

本文选题：尼可地尔 + 心肌梗死　；参考：《新疆医科大学》2013年硕士论文

【摘要】：目的:探讨评价尼可地尔对急性心肌梗死再灌注疗效有效性,为制定临床合理的急性心肌梗死治疗方案提供高质量依据。方法:计算机检索Cochrane图书馆（2012年第3期）、Pubmed、EMbase、Highwire、CBM、CNKI等中外生物医学数据库。收集关于尼可地尔对急性心肌梗死再灌注疗效方面的临床随机对照试验，检索日期截止至2012年3月。按Cochrane系统评价方法，评价所纳入研究的文献质量，并提取有效数据后采用RevMan5.1软件进行Meta分析。结果:纳入11项研究，，共计1027名患者。Meta分析结果显示：急性心肌梗死再灌注患者接受尼可地尔治疗，降低再灌注后无复流或慢血流率[RR=0.34,95%CI(0.19,0.61)],提高心脏左室射血分数[MD=5.49,95%CI(4.51,6.47)],降低左室舒张末期容积[MD=-14.38,95%CI(-17.31,-11.45)]。降低心脏不良事件发生率[RR=0.34,95%CI(0.25,0.46)]、再入院率[RR=0.33,95%CI(0.17,0.63)]及死亡率[RR=0.40,95%CI(0.16,0.97)]。结论:证据表明,急性心肌梗死再灌注患者接受尼可地尔治疗，增加患者冠状动脉微循环，改善患者预后,可以降低心脏不良事件发生率、再入院率及死亡率。
[Abstract]:Objective: to evaluate the efficacy of nicordil in the treatment of acute myocardial infarction (AMI). Methods: Chinese and foreign biomedical databases such as Cochrane Library (issue 3, 2012) were searched by computer. To collect clinical randomized controlled trials on the efficacy of nicordil in the treatment of acute myocardial infarction reperfusion, the retrieval date was up to March 2012. According to the evaluation method of Cochrane system, the quality of literature included in the study was evaluated, and the valid data were extracted and analyzed by Meta software RevMan5.1. Results: in 11 studies, a total of 1027 patients. Meta-analysis showed that patients with acute myocardial infarction and reperfusion received nicorandil therapy. It also decreased the rate of no reflow or slow flow after reperfusion [RRV 0.34 ~ 95CI0.19 ~ 0.61], increased the left ventricular ejection fraction [MDV 5.49 ~ 95 CI 4.51 ~ 6.47], and decreased the left ventricular end-diastolic volume [MD-14.3895 CI-17.31 ~ (-1 ~ -11.45)]. To reduce the incidence of adverse cardiac events [RRV 0.34 / 95 CI 0.25 / 0.46], readmission rate [RRN 0.33 / 95 CI = 0.17 / 0.63] and mortality rate [RRN 0.40 / 95 CI 0.16 / 0.97]. Conclusion: the evidence shows that nicorandil can increase coronary microcirculation and improve prognosis in patients with acute myocardial infarction reperfusion. It can reduce the incidence of adverse cardiac events, readmission rate and mortality.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R542.22

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