皮质—丘脑—皮质环路在急性脑卒中后皮层功能重构中的作用

发布时间：2018-04-21 22:43

本文选题：丘脑 + 局部一致性　；参考：《中国科学技术大学》2015年硕士论文

【摘要】：本篇毕业论文用静息态功能磁共振成像数据研究了急性脑卒中后皮质-丘脑-皮质环路在皮层功能重构过程中的作用。之前的很多研究已经发现脑卒中后的运动恢复和皮层功能重构相关而且脑卒中后运动功能的恢复中会有丘脑激活情况的变化。而丘脑可以通过皮质-丘脑-皮质环路来调节各个皮层区域之间的激活。为了研究脑卒中后皮层功能重组是否和皮质-丘脑-皮质环路有关,本研究把脑卒中被试分为两个组：UP group-皮质-丘脑-皮质环路正常的病人(即从丘脑传出的信息流正常,共16个脑卒中被试)；DOWN group-皮质-丘脑-皮质环路受损病人(即从丘脑传出的信息流受损,共10个脑卒中被试)。然后,我们采集了静息态功能磁共振数据来研究了两组病人和正常对照组(H group,共招募了19名正常健康被试)的大脑局部一致性。我们的结果发现,和健康对照组相比,UP group在双侧丘脑和记忆相关的脑区：双侧海马旁回的局部一致性显著增加,在感觉系统的输入和整合相关的脑区：左侧楔前叶／楔叶和左侧颞中回的局部一致性显著降低。而和健康对照组相比,DOWN group只在双侧楔叶／楔前叶和右侧顶下小叶局部一致性显著降低而没有脑区有显著增强的局部一致性。此外,在UP group中左侧丘脑和左内侧额叶、右侧梭状回和右侧颞中回之间的功能连接比H group要高,而在DOWN group中只发现左侧丘脑和左内侧额叶之间的功能连接增高。并且和H group比,不论UP group还是DOWN group都没有发现大脑拓扑结构的改变。我们的结果暗示由于脑卒中导致的躯体感觉系统的受损而在记忆系统发生的补偿作用仅仅发生在从丘脑传出的信息流正常没有受损的脑卒中病人上,而且这种效应可能影响的是一种特定的丘脑网络而不是全脑的大脑功能网络。结论：总的来说,我们的结果暗示当脑卒中病人的皮质-丘脑-皮质环路没有受损的时候会发生更好的脑卒中后皮层功能重构而且这种效应可能影响的是一种特定的丘脑网络而不是全脑的大脑功能网络。这一结果暗示皮质-丘脑-皮质环路可能在脑卒中后皮层功能重组中非常重要。我们的研究中采用的分类方法可能提供了一个新的研究思路。另外皮质-丘脑-皮质环路在皮层功能重组中可能的重要作用可以为临床上的脑卒中后康复提供一个新的方向。
[Abstract]:The role of cortex-thalamic-cortical loop in cortical functional remodeling after acute stroke was studied using resting functional magnetic resonance imaging (fMRI) data. Many previous studies have found that motor recovery after stroke is associated with cortical functional remodeling and that there are changes in thalamic activation in the recovery of motor function after stroke. The thalamus can regulate the activation of various cortical regions through the cortical-thalamic-cortical loop. In order to study whether the functional recombination of the cortex after stroke is related to the cortex-thalamus-cortical loop, the subjects were divided into two groups: the normal flow of information from the thalamus. A total of 16 stroke subjects were involved in the impaired DOWN group- cortex-thalamo-cortical loop (i.e., the information flow from the thalamus was impaired, and 10 stroke subjects were involved. Then we collected resting functional magnetic resonance data to study the local consistency of brain in two groups of patients and a control group of 19 healthy subjects. Our results showed that the local consistency of up group in bilateral thalamic and memory-related brain regions was significantly increased compared with that in healthy controls. In the sensory system input and integration-related areas: the local consistency of the left anterior cuneiform / cuneate lobe and left middle temporal gyrus decreased significantly. Compared with the healthy control group, the local consistency of don group in bilateral cuneiform / precuneiform lobe and right inferior parietal lobule was significantly lower than that in the control group, but there was no significant enhancement of local consistency in the brain region. In addition, the functional junctions between left thalamus and left medial frontal lobe, right fusiform gyrus and right middle temporal gyrus in up group were higher than those in H group, but in DOWN group only the functional connections between left thalamus and left medial frontal lobe were increased. Compared with H group, neither up group nor DOWN group found any changes in brain topology. Our results suggest that the compensatory effect of the memory system on the memory system due to the impairment of the somatosensory system caused by stroke occurs only in stroke patients whose flow of information from the thalamus is normal and not impaired. And this effect may affect a specific thalamic network rather than the brain function network of the whole brain. Conclusion: in general, Our results suggest that better cortical remodeling occurs when the cortex-thalamus-cortical loop is not impaired in stroke patients and that this effect may affect a specific thalamic network rather than a It's a network of brain functions throughout the brain. The results suggest that the cortical-thalamic-cortical loop may be important in the reconstitution of cortical function after stroke. The classification method used in our study may provide a new approach to research. In addition, the cortex-thalamic-cortical loop may play an important role in cortical functional reorganization, which may provide a new direction for clinical rehabilitation after stroke.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R743.3

【参考文献】