抗菌肽在脓毒症治疗中的应用进展

发布时间：2018-04-27 06:24

本文选题：抗菌肽 + 脓毒症　；参考：《上海交通大学学报(医学版)》2017年08期

【摘要】：脓毒症是一种严重的全身炎症反应综合征,临床上常见于感染、大面积烧伤和外科术后患者;可继发脓毒性休克及多器官功能衰竭,病死率高,预后较差,目前尚无有效的治疗手段。传统的抗生素在杀伤细菌的过程中可使脂多糖等致炎因子大量释放入血,进一步加剧免疫系统的失调,而近年来多重耐药菌的出现更是为脓毒症的治疗带来严峻的挑战。抗菌肽是一类两亲性阳离子多肽,对细菌、真菌及病毒等具有广泛的杀伤作用,同时能够中和内毒素,并通过其免疫调节作用抑制炎症细胞因子的产生,在脓毒症的治疗中展现出了良好的应用前景。该文综述了抗菌肽在脓毒症治疗中的应用进展及相关分子机制。
[Abstract]:Sepsis is a severe systemic inflammatory response syndrome, which is commonly seen in patients with infection, extensive burn and postoperative surgery, and can be secondary to septic shock and multiple organ failure, with high mortality and poor prognosis. At present, there is no effective treatment. Traditional antibiotics can release lipopolysaccharide and other inflammatory factors into blood in the process of killing bacteria, which further aggravate the imbalance of immune system. In recent years, the emergence of multidrug resistant bacteria has brought severe challenges to the treatment of sepsis. Antimicrobial peptides are a kind of amphiphilic cationic peptides, which can kill bacteria, fungi and viruses, and can neutralize endotoxin and inhibit the production of inflammatory cytokines through its immunomodulation. In the treatment of sepsis showed a good application prospects. This article reviews the application and molecular mechanism of antimicrobial peptides in the treatment of sepsis.
【作者单位】：上海交通大学医学院附属第九人民医院肾脏科危重肾脏病研究室;
【基金】：国家自然科学基金(81270850,81470990) 上海市浦东新区卫生与计划生育委员会联合攻关项目(PW2015D-4) 上海交通大学医工交叉重点项目(YG2014ZD06)~~
【分类号】：R459.7

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