替加环素注射剂治疗多重耐药菌感染老年危重症患者的疗效分析

发布时间：2018-04-27 23:37

  本文选题：替加环素注射剂 + 老年危重症　； 参考：《中国临床药理学杂志》2017年14期

【摘要】：目的分析替加环素注射剂治疗多重耐药菌感染老年危重症患者的预测因素。方法回顾性分析40例应用替加环素治疗多重耐药菌感染老年危重症患者的临床资料。所有患者均予以替加环素静脉注射,首剂100 mg,之后每次50~100 mg,q12 h,疗程4~19 d。根据感染是否得到控制将治疗结局分为有效组22例和无效组18例。比较2组患者的实验室指标、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)、序贯器官衰竭评估(SOFA)、简化急性生理学评分Ⅱ(SAPSⅡ)。用受试者工作特征曲线(ROC曲线)评估APACHEⅡ评分、SOFA评分和SAPSⅡ评分对替加环素疗效的预测价值。结果治疗前和治疗后,有效组的肌酐清除率(Ccr)分别为(64.44±27.24),(71.78±30.38)mL·min~(-1),降钙素原(PCT)分别为0.41(0.05,25.00)ng·mL~(-1)和0.13(0.05,4.00)ng·mL~(-1),差异均有统计学意义(均P0.05)。治疗前和治疗后,无效组Ccr分别为(58.34±28.18),(47.58±31.91)mL·min~(-1),APACHEⅡ评分分别为(25.06±10.18),(30.83±14.71)分,SOFA评分分别为(9.89±5.32),(12.78±5.75)分,SAPSⅡ评分分别为(60.39±20.18),(72.33±22.72)分,差异均有统计学意义(均P0.05)。APACHEⅡ评分、SOFA评分和SAPSⅡ评分预测替加环素治疗无效的ROC曲线下面积分别为0.73,0.74和0.78,差异有统计学意义(均P0.05)。结论 APACHEⅡ评分、SOFA评分和SAPSⅡ评分对替加环素治疗多重耐药菌感染老年危重症患者的疗效具有一定的预测意义。
[Abstract]:Objective to analyze the predictive factors of tigicycline injection in the treatment of multidrug resistant bacteria infection. Methods the clinical data of 40 patients with multidrug resistant bacteria infection were analyzed retrospectively. All patients were treated with tegicycline intravenously, the first dose was 100 mg, and then 50 mg / kg Q12 / h for 4 days (19 days). The outcome of treatment was divided into effective group (22 cases) and ineffective group (18 cases) according to whether infection was controlled or not. The laboratory indexes, acute physiological and chronic health status score 鈪，

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