腱糖蛋白C在急性心肌梗死患者血清中浓度变化及与左室重构的关系

发布时间：2018-04-29 15:52

  本文选题：腱糖蛋白C + 急性心肌梗死　； 参考：《广西医科大学》2013年硕士论文

【摘要】：目的：观察急性心肌梗死患者入院后腱糖蛋白C (Tenaseins-C, TN-C)血清中浓度的变化与左室重构的关系。 方法：收集60例AMI患者以及19例诊断明确UA患者与20例体检正常对照者。用ELISA法测定急诊送入CCU的患者即刻血清中TN-C、发病后第3天、第7天血清中TN-C浓度水平变化及入院CRP、cTn-T的峰值。首次发病住院心脏彩超及3个月后随访复查,测定EF、FS、LVEDV、LVESV作为左心室容积指标。并根据左心室舒张末期容积指数LVEDVI (LVEDV/体表面积BSA)作为研究观察指标,LVEDVI≤20%作为非重构组,LVEDVI20%作为重构组。用SPSS13.0统计软件包进行统计学分析。结果：(1)AMI组患者入院后即刻TN-C浓度明显高于正常对照组(P0.05),同时也明显高于UA组(P0.05),AMI患者第3天血清中TN-C浓度在高于入院即测(P0.05),也明显高于第7天测定浓度(P0.05)。(2)第3天血清TN-C浓度与CRP呈正相关(r=0.310,P0.05),与cTn-T呈正相关(r=0.820,P0.05)。(3)AMI组TN-C峰值浓度与心梗急性期心脏彩超测定EF值呈负相关(r=-0.820,P0.05),TN-C浓度峰值与FS呈负相关(r=-0.277,P0.05)。(4)随访左心室重构发生率32.69%,经pearson相关性分析提示TN-C峰值浓度与重构组LVEDVI呈正相关(r=0.839,P0.05),与ΔLVEDVI成正相关 (r=0.761,P0.05),logistics回归分析及ROC曲线分析显示TN-C与左心室重构相关。 结论：AMI患者急性期TN-C浓度水平明显高于UA患者及正常对照组,心梗发生后第3天血清TN-C浓度可出现较高浓度表达,与CRP浓度、cTn-T呈正相关,与心脏射血分数EF、左室短轴缩短率FS呈负相关。AMI患者血清TN-C峰值水平与心室重构可能密切相关,具有一定的临床判断意义。
[Abstract]:Aim: to observe the relationship between the serum concentration of tenaseins-C (TN-C) and left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods: 60 patients with AMI, 19 patients with definite UA and 20 normal controls were collected. The serum TN-Cwas measured by ELISA method in the patients who were admitted to CCU immediately. The serum TN-C level and the peak value of CRPcTn-T were measured on the 3rd and 7th day after the onset of the disease. Echocardiography was performed for the first time and followed up for 3 months to determine the left ventricular volume (LVV) of EFFSV DVV and LVESV. The left ventricular end-diastolic volume index (LVEDVI) was used as the index of LVEDVI 鈮，

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