重组人生长激素治疗老年重度烧伤患者的临床观察

发布时间：2018-05-03 04:02

本文选题：重组人生长激素 + 重度烧伤　；参考：《中国药房》2016年23期

【摘要】：目的:探讨重组人生长激素(HGH)对老年重度烧伤患者血清内毒素、炎症因子、创面愈合时间、住院时间及预后的影响。方法:选取在我院治疗的老年重度烧伤患者96例,按随机数字表法分为治疗组和对照组,各48例。两组患者均给予创伤面护理、营养支持,维持水、电解质及酸碱平衡;对照组患者皮下注射0.9%氯化钠注射液1 ml,qd;治疗组患者给予注射用HGH 0.3 IU/kg皮下注射,qd。两组患者均治疗21 d。比较两组患者治疗前及治疗14、21 d后的血清内毒素含量,观察两组患者治疗前后血清炎症因子[肿瘤坏死因子(TNF)α、白细胞介素(IL)6、IL-8]水平和创面愈合时间、住院时间,计算两组患者多器官障碍综合征(MODS)、死亡、全身感染的发生率。结果:两组患者治疗前及治疗14 d后的内毒素含量比较,差异无统计学意义(P0.05);治疗21 d后,两组患者血清内毒素含量明显降低,且治疗组患者明显低于对照组,差异有统计学意义(P0.05)。治疗后,治疗组患者IL-8水平明显高于对照组,TNF-α、IL-6明显低于对照组,差异均有统计学意义(P0.05)。治疗组患者各创面愈合时间及住院时间均显著短于对照组,差异均有统计学意义(P0.05);治疗组患者MODS、死亡及全身感染的发生率均显著低于对照组,差异均有统计学意义(P0.05)。结论:HGH能使老年重度烧伤患者吸收的毒素减少,改善炎症因子水平,从而促进患者创面愈合及改善预后。
[Abstract]:Objective: to investigate the effects of recombinant human growth hormone (HGH) on serum endotoxin, inflammatory factors, wound healing time, hospital stay and prognosis in elderly patients with severe burn. Methods: 96 elderly patients with severe burn were randomly divided into treatment group (n = 48) and control group (n = 48). The patients in both groups were given trauma care, nutritional support, water, electrolyte and acid-base balance, the control group was subcutaneously injected with 0.9% sodium chloride injection 1 ml QD, and the treatment group was subcutaneously injected with HGH 0.3 IU/kg. The patients in both groups were treated for 21 days. The serum endotoxin levels before and after 14 days treatment were compared between the two groups. The levels of serum inflammatory factor (TNFa) 伪, interleukin-6 IL-8 (IL-8), wound healing time and hospitalization time were observed before and after treatment. The incidence of MODS, death and systemic infection in patients with multiple organ dysfunction syndrome were calculated. Results: there was no significant difference in endotoxin content between the two groups before treatment and 14 days after treatment, but after 21 days of treatment, the serum endotoxin level in the two groups was significantly lower than that in the control group, and the level of endotoxin in the treatment group was significantly lower than that in the control group. The difference was statistically significant (P 0.05). After treatment, the level of IL-8 in the treatment group was significantly higher than that in the control group, and the level of TNF- 伪 and IL-6 in the treatment group was significantly lower than that in the control group (P 0.05). The healing time and hospitalization time of each wound in the treatment group were significantly shorter than those in the control group (P 0.05), and the incidence of MODS, death and systemic infection in the treatment group were significantly lower than those in the control group (P 0.05). ConclusionHGH can reduce the absorption of toxin and improve the level of inflammatory factors in the elderly patients with severe burn, thus promoting wound healing and improving prognosis.
【作者单位】：四川省医学科学院/四川省人民医院烧伤科;
【分类号】：R644

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