5-HT信号传导通路相关基因多态性与驾驶员事故倾向性的关联

发布时间：2018-05-03 12:08

本文选题：驾驶员 + 事故倾向性　；参考：《中国公共卫生》2016年04期

【摘要】：目的探讨5-羟色胺(5-HT)信号传导通路相关基因位点多态性与驾驶员事故倾向性的关联。方法研究对象来自2014年在广西工人医院体检的驾驶员,通过问卷调查将过去5年中发生≥3次责任交通事故的驾驶员纳入病例组,对照组按年龄、性别、驾驶车型、驾龄与病例组进行成组匹配;对G蛋白β3亚基(GNβ3)基因rs5443位点、脑源性神经营养因子(BDNF)基因rs6265位点和反应元件结合蛋白(CREB)基因rs6740584位点进行单核苷酸多态性(SNP)基因分型。结果 rs5443位点基因型频率分布在病例组与对照组分布有统计学差异(χ2=7.20,P=0.027),rs6265和rs6740584位点基因型频率在2组分布均无统计学差异(均P0.05);携带rs5443位点突变基因型TT可降低事故倾向性风险,rs6265和rs6740584位点多态性在调整前后与驾驶员事故倾向性均无统计学关联。结论 GNβ3基因rs5443多态性与驾驶员的事故倾向性可能有关联。
[Abstract]:Objective to investigate the association between the polymorphism of 5 HT signal transduction pathway related gene loci and driver accident tendency. Methods the subjects of the study were drivers who were examined in Guangxi Workers Hospital in 2014. The drivers who had more than 3 traffic accidents in the past 5 years were included in the case group. The control group was controlled by age, sex and type of driving. The driving age was matched with the patient group, and the single nucleotide polymorphisms (SNPs) were performed on the rs5443 site of G protein 尾 3 subunit, the rs6265 site of brain-derived neurotrophic factor (BDNF) gene and the rs6740584 locus of response element binding protein (CREBB) gene. Results there was significant difference in the distribution of genotype frequency of rs5443 locus between the case group and the control group (蠂 27.20) and the genotype frequency of rs6740584 locus were not significantly different between the two groups (all P 0.05), TT with rs5443 locus mutation genotype could reduce the accident. Neither Rs6265 nor rs6740584 polymorphism was associated with driver accident tendency before and after adjustment. Conclusion the rs5443 polymorphism of GN 尾 3 gene may be associated with driver's accident tendency.
【作者单位】：广西医科大学公共卫生学院职业卫生与环境卫生教研室;
【基金】：广西自然科学基金(2013GXNSFDA019017) 国家自然科学基金(81560528) 广西高校科学技术研究项目(KY2015YB064)
【分类号】：R641

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