感染性休克患者血必净治疗前后LA与CRP及PCT变化研究

发布时间：2018-05-04 00:19

本文选题：感染性休克 + 血必净　；参考：《中华医院感染学杂志》2016年20期

【摘要】：目的通过探讨感染性休克患者血必净治疗前后LA、CRP、PCT及血流动力学的变化,观察血必净治疗感染性休克的临床疗效。方法选择2014年8月-2015年9月医院接收的感染性休克患者192例,分为观察组与对照组各96例,对照组患者以常规方法进行治疗,观察组患者在常规治疗基础上以血必净治疗,观察其临床效果。结果经治疗后,两组患者血流动力学指标变化均有一定程度改善,但观察组患者治疗后HR(75.5±9.6)次/min、CI(3.9±0.5)L/min/m2、CVP(80.5±4.6)mmHg以及MAP(77.4±2.7)mmHg与PAWP(14.8±1.1)mmHg改善情况明显优于对照组,差异有统计学意义(P0.05);两组患者LA、CRP、PCT指标变化均有所降低,但观察组患者治疗后LA(1.5±0.6)mmol/L、CRP(14.4±3.2)mg/L、PCT(1.5±0.3)ng/L,降低程度大于对照组,差异有统计学意义(P0.05);观察组患者死亡率为12.5%,明显低于对照组35.5%,差异有统计学意义(P0.05);两组患者肺水肿发生率比较,差异无统计学意义。结论血必净治疗感染性休克患者效果较好,可使其血流动力学得到有效改善,并且能够对炎性反应进行有效抑制,促使其尽快康复。
[Abstract]:Objective to investigate the changes of PCT and hemodynamics in patients with septic shock before and after Xuebijing treatment, and to observe the clinical effect of Xue Bijing on septic shock. Methods 192 patients with septic shock received from August 2014 to September 2015 were divided into two groups: the observation group (n = 96) and the control group (n = 96). The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with Xuebijing on the basis of routine treatment. The clinical effect was observed. Results after treatment, the changes of hemodynamic indexes in both groups were improved to a certain extent, but the improvement of HR(75.5 卤9.6 times / r / min CI = 3.9 卤0.5 L / min / m ~ (2) C _ (2) 4.6)mmHg, MAP(77.4 卤2.7)mmHg and PAWP(14.8 卤1.1)mmHg in the observation group was significantly better than that in the control group. The difference was statistically significant (P 0.05), but the LA(1.5 卤0.6 mmol / L CRP P / L in the observation group was 14.4 卤3.2 mg / L, 1.5 卤0.3 ng / L, which was significantly lower than that in the control group, and the difference was significant between the two groups, but the changes of the LA(1.5 卤0.6 mmol / L CRP / L in the observation group were significantly lower than those in the control group (P < 0.05), but the decrease was higher in the observation group than that in the control group (P < 0.05). The mortality rate of patients in the observation group was 12.5, which was significantly lower than that in the control group (35.5g), and the difference was statistically significant (P 0.05). There was no significant difference in the incidence of pulmonary edema between the two groups. Conclusion Xuebijing is effective in the treatment of septic shock patients. It can effectively improve hemodynamics, inhibit inflammatory reaction and promote its recovery as soon as possible.
【作者单位】：滨州市人民医院急诊科;滨州市人民医院随访中心;滨州市沾化区人民医院护理部;滨州市沾化区人民医院感染科;
【基金】：国家自然科学基金资助项目(30772808)
【分类号】：R459.7

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