尤瑞克林治疗急性分水岭脑梗死患者的疗效观察

发布时间：2018-05-05 06:03

本文选题：尤瑞克林 + 分水岭脑梗死　；参考：《中国药房》2016年05期

【摘要】：目的:观察尤瑞克林治疗急性分水岭脑梗死(WSI)的临床疗效。方法:将128例急性(WSI)患者,按随机数字表法分为对照组和治疗组,各64例。对照组患者给予舒血宁注射液15 ml加入0.9%氯化钠注射液250 ml,ivgtt,qd;治疗组患者采用注射用尤瑞克林0.15 PNA单位加入0.9%氯化钠注射液100 ml,ivgtt,qd,两组患者均连续治疗14 d。观察两组患者治疗前及治疗后3、7、14 d神经功能缺损评分和临床疗效,并取两组患者治疗后7、14 d血液标本,测定血清补体末端复合体(TCC)水平。结果:治疗后,治疗组患者神经功能缺损评分及总有效率均显著高于对照组,差异有统计学意义(P0.01);治疗前,两组患者TCC水平比较,差异无统计学意义(P0.05),治疗后7 d,两组患者TCC水平均显著升高,至14 d时,又有所下降,且治疗组低于对照组,差异有统计学意义(P0.05)。结论:尤瑞克林能明显提高急性WSI患者临床疗效,改善患者神经功能缺损症状及TCC水平。
[Abstract]:Objective: to observe the clinical effect of eucrine in the treatment of acute watershed cerebral infarction (WSI). Methods: 128 patients with acute WSI were randomly divided into control group (n = 64) and treatment group (n = 64). The patients in the control group were treated with suxuening injection 15 ml and 0.9% sodium chloride injection 250ml iv QD, while the patients in the treatment group were treated continuously for 14 days with the addition of 0.9% sodium chloride injection 100ml iv PNA unit for injection. The neurological deficit score and clinical efficacy of the two groups were observed before and after treatment. The blood samples of the two groups were collected at 7 and 14 days after treatment, and the serum TCCs were measured. Results: after treatment, the neurological deficit score and the total effective rate of the patients in the treatment group were significantly higher than those in the control group, and the difference was statistically significant (P0.01). There was no significant difference between the two groups (P 0.05). At 7 days after treatment, the level of TCC in both groups increased significantly, and then decreased at 14 days, and the treatment group was lower than that of the control group, the difference was statistically significant (P 0.05). Conclusion: Urethrin can significantly improve the clinical efficacy of acute WSI patients, improve the neurological deficit symptoms and TCC level.
【作者单位】：牡丹江医学院第二附属医院医保科;牡丹江医学院第二附属医院药剂科;牡丹江医学院第二附属医院神经内科;牡丹江医学院第二附属医院老年病科;
【基金】：牡丹江医学院科学技术研究项目(No.ZS201522)
【分类号】：R743.3

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