Toll样受体及T淋巴细胞亚群与脓毒症的关系分析

发布时间：2018-05-06 18:58

本文选题：Toll样受体 + T淋巴细胞亚群　；参考：《中华医院感染学杂志》2016年22期

【摘要】：目的分析及研究Toll样受体及T淋巴细胞亚群与脓毒症的关系,以为脓毒症的诊治提供依据。方法选取2015年1月-2016年4月医院诊治55例脓毒症患者为观察组,另选取同期55名健康体检者为对照组,比较两组研究对象外周血单核细胞Toll样受体(TLR-2、TLR-4、TLR-7及TLR-9)及T淋巴细胞亚群指标,然后比较观察组中不同严重程度脓毒症患者上述血液指标,同时采用logistic分析Toll样受体及T淋巴细胞亚群与脓毒症的关系。结果观察组TLR-2、TLR-4、TLR-7及TLR-9水平分别为(39.89±3.59)%、(17.33±1.60)%、(18.85±1.79)%及(62.68±7.32)%,其均高于对照组(16.16±1.53)%、(8.20±0.71)%、(3.31±0.28)%及(41.51±5.20)%;T淋巴细胞亚群指标均低于对照组,且观察组中脓毒症、严重脓毒症及脓毒性休克患者的检测水平也存在明显差异;经logistic分析,Toll样受体及T淋巴细胞亚群均与脓毒症有密切的关系,差异有统计学意义(P0.05)。结论脓毒症患者Toll样受体及T淋巴细胞亚群指标呈现明显异常状态,且其严重程度对上述指标的表达影响较大,应重视对上述指标的监测与改善。
[Abstract]:Objective to study the relationship between Toll-like receptor and T-lymphocyte subsets and sepsis in order to provide evidence for diagnosis and treatment of sepsis. Methods from January 2015 to April 2016, 55 patients with sepsis were selected as observation group and 55 healthy persons as control group. The peripheral blood monocyte Toll like receptor TLR-2TLR-4 TLR-7 and TLR-9) and T lymphocyte subsets were compared between the two groups. At the same time, logistic was used to analyze the relationship between Toll like receptor and T lymphocyte subsets and sepsis. Results the levels of TLR-2, TLR-4, TLR-7 and TLR-9 in the observation group were 39.89 卤3.59 and 17.33 卤1.60, 18.85 卤1.79% and 62.68 卤7.32%, respectively, which were higher than those in the control group (16.16 卤1.53), 8.20 卤0.28% and 41.51 卤5.20%, respectively. Logistic analysis showed that Toll-like receptors and T lymphocyte subsets were closely related to sepsis, and the difference was statistically significant (P 0.05). Conclusion the indexes of Toll like receptor and T lymphocyte subsets in patients with sepsis are obviously abnormal, and their severity has a great influence on the expression of these indexes. Therefore, attention should be paid to the monitoring and improvement of the above indexes.
【作者单位】：第二军医大学长海医院麻醉科;
【基金】：国家自然科学基金资助项目(81272065)
【分类号】：R459.7

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