早期使用前列地尔治疗急性脑梗死的临床观察

发布时间：2018-05-06 22:37

本文选题：急性脑梗死 + 前列地尔　；参考：《中国药房》2016年26期

【摘要】：目的:探讨早期使用前列地尔治疗急性脑梗死的疗效,及其对患者血浆正五聚体蛋白(PTX)3、肾功能与颈动脉斑块稳定性的影响。方法:选取我院2011年8月-2015年8月收治的急性脑梗死患者93例,根据就诊顺序进行编号,并按照就诊顺序单双号依次纳入观察组(47例,2例病例脱落,共45例完成研究)和对照组(46例,1例病例脱落,共45例完成研究)。对照组患者给予胞磷胆碱钠注射液0.5 g~+银杏叶提取物注射液20 ml加入0.9%氯化钠注射液(NS)250 ml中,ivgtt,qd;观察组患者在此基础上给予前列地尔注射液20μg加入NS 250 ml中,ivgtt,qd。两组患者疗程均为2周。观察两组患者的临床疗效,治疗前后PTX-3、血尿素氮(BUN)、血清肌酐(SCr)、24 h尿蛋白定量(Upro)、颈动脉斑块稳定性的差异以及不良反应发生情况。结果:观察组患者总有效率(91.1%)明显高于对照组(73.3%),差异有统计学意义(P0.05)。治疗前,两组患者PTX-3、BUN、SCr和24 h Upro比较,差异无统计学意义(P0.05)。治疗后,两组患者PTX-3、BUN、SCr和24 h Upro均明显降低,且观察组患者明显低于对照组;观察组患者斑块稳定性(100.0%)亦明显高于对照组(64.0%),差异均有统计学意义(P0.05)。两组患者出现的不良反应未进行特殊处理均自行缓解,且差异无统计学意义(P0.05)。结论:早期使用前列地尔治疗急性脑梗死疗效较好,可明显降低患者PTX-3,改善肾功能,提高颈动脉斑块稳定性,且安全性较好。
[Abstract]:Objective: to investigate the effect of early use of alprostadil on acute cerebral infarction and its effects on plasma pentagglutinin (PTX3), renal function and carotid plaque stability. Methods: 93 patients with acute cerebral infarction admitted in our hospital from August 2011 to August 2015 were selected and numbered according to the order of visit. According to the order of visit, 47 patients with acute cerebral infarction in the observation group were included in the observation group. A total of 45 cases completed the study) and the control group of 46 cases (1 case) dropped off, a total of 45 cases completed the study. The patients in the control group were given citicoline sodium injection 0.5 g ~ Ginkgo biloba extract injection 20 ml, and the patients in the observation group were given 20 渭 g alprostadil injection added to NS 250 ml iv gttt QD in 0.9% sodium chloride injection NS250 ml, and the patients in the observation group were given alprostadil injection 20 渭 g plus NS 250 ml iv gttt QD. The course of treatment was 2 weeks. The clinical efficacy, PTX-3, blood urea nitrogen bun, serum creatinine, 24 h urinary protein, carotid plaque stability and the occurrence of adverse reactions were observed. Results: the total effective rate of patients in the observation group (91.1%) was significantly higher than that in the control group (73.3%), and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference between the two groups in PTX-3 bun SCR and 24 h Upro (P 0.05). After treatment, the levels of PTX-3 bun SCR and 24 h Upro in the observation group were significantly lower than those in the control group, and the plaque stability in the observation group was significantly higher than that in the control group (P 0.05). The adverse reactions of the two groups were not relieved by special treatment, and the difference was not statistically significant (P 0.05). Conclusion: early use of alprostadil in the treatment of acute cerebral infarction can significantly reduce PTX-3, improve renal function, improve the stability of carotid plaque, and the safety is good.
【作者单位】：无锡市第二人民医院神经内科;
【分类号】：R743

【相似文献】