72h内动态监测降钙素原在急性脑卒中并发感染患者中的应用研究

发布时间：2018-05-07 08:03

本文选题：脑卒中 + 并发感染　；参考：《中华医院感染学杂志》2017年19期

【摘要】：目的探讨72h内动态监测血清降钙素原(PCT)在急性脑卒中并发感染患者中的应用价值。方法选取在2012年3月-2017年2月医院收治的急性脑卒中患者103例,根据微生物学检查结果分为感染组42例与非感染组61例,比较观察两组患者在24h、36h、72h的血清降钙素原(PCT)变化在病理因素中的差异及对病情的影响。结果 103例脑卒中患者中有42例患者并发感染,感染率为40.78%,其中两组患者的年龄、合并症种类、病灶体积及美国国立卫生研究院卒中量表(NIHSS)评分均有显著差异(P均0.05);感染组患者的PCT在24h、36h、72h的检测结果分别为(1.447±0.083)μg/L、(4.926±0.376)μg/L、(9.238±1.652)μg/L明显高于非感染组(0.354±0.027)μg/L、(3.071±0.238)μg/L、(5.636±0.794)μg/L(P均0.05);NIHSS中度和重度的感染组患者在72h内各时间点的PCT检测数值与非感染组患者之间存在差异(P均0.05),而评分轻度患者组间PCT检查结果未见明显差异;感染组患者的死亡率为26.19%明显高于非感染组的3.28%(P均0.05)。结论急性脑卒中并发感染患者的PCT数值显著升高,指标水平越高反映病情越重,在72h内动态检测PCT对脑卒中患者的诊断和预后都具有一定的临床价值。
[Abstract]:Objective to investigate the value of dynamic monitoring of serum calcitonin (PCT) in patients with acute cerebral apoplexy complicated with infection in 72h. Methods 103 patients with acute cerebral apoplexy treated in hospital in February, March 2012 were selected. According to the results of Microbiology, 42 cases of infection group and 61 cases of non infection group were divided into two groups of patients in 24h, 36h, 72h. The difference of serum calcitonin (PCT) changes in pathological factors and its effect on the disease. Results of 103 stroke patients, 42 cases were infected with infection rate of 40.78%. The age of the two groups, the type of complication, the volume of the lesion and the National Institutes of Health Stroke Scale (NIHSS) score were significantly different (P 0.05). The detection results of PCT in 24h, 36h, and 72h in the infected group were (1.447 + 0.083) mu g/L, (4.926 + 0.376) mu g/L and (9.238 + 1.652) mu g/L significantly higher than that of non infection group (0.354 + 0.027) mu g/L, (3.071 + 0.238) mu g/L, (5.636 + 0.794) mu g/L (P all 0.05). There was a difference between the patients in the dyed group (P 0.05), but there was no significant difference in the results of PCT between the patients with mild scores. The mortality of the patients in the infection group was 26.19% significantly higher than that of the non infected group (P 0.05). Conclusion the PCT value of the patients with acute cerebral apoplexy was significantly higher, the higher the index level was, the more serious the disease was, the dynamic of the disease was in the 72h. Detection of PCT has certain clinical value in the diagnosis and prognosis of stroke patients.

【作者单位】：遵义市第一人民医院神经内科;遵义市第一人民医院检验科;遵义医学院第一附属医院重症医学科;
【分类号】：R743.3

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