血清胱抑素C水平在缺血性卒中患者急性期及其亚型中的变化和意义

发布时间：2018-05-09 23:06

本文选题：缺血性卒中 + 胱抑素C　；参考：《中国脑血管病杂志》2016年04期

【摘要】：目的分析血清胱抑素C(Cys-C)在急性缺血性卒中患者及其中国缺血性卒中亚型(CISS)中的表达和意义。方法回顾性纳入2014年8月至2015年4月于兰州大学第二医院神经内科住院的200例首发急性缺血性卒中患者作为观察组,入选同期健康体检及住院的非脑血管疾病患者136例作为对照组。按照CISS分型标准对缺血性卒中患者进行病因分型,检测所有患者的空腹血清Cys-C水平。采用多因素非条件Logistic回归分析缺血性卒中及其亚型与Cys-C水平的关系。结果 (1)观察组患者及其大动脉粥样硬化性(LAA)、心源性卒中(CS)、穿支动脉疾病(PAD)亚组患者血清Cys-C水平均高于对照组(1.06±0.25)、(1.12±0.23)、(1.17±0.42)、(1.01±0.21)mg/L比(0.94±0.16)mg/L,均P㩳0.05);(2)LAA亚组患者血清Cys-C水平高于PAD亚组患者(P㩳0.05);(3)Logistic回归分析结果显示,高水平血清Cys-C是缺血性卒中的危险因素(OR=19.148,95%CI:3.814~96.133,P㩳0.001);将观察组与对照组合并后,按照血清Cys-C水平进行五分位数划分,调整其他因素影响后,最高五分位数血清Cys-C水平对缺血性卒中影响显著(OR=4.461,95%CI:1.599~12.443,P0.05),并且血清Cys-C水平处于最高五分位数时,对LAA型影响更为明显(OR=7.075,95%CI:1.883~26.589,P=0.004)。结论血清Cys-C水平升高可能是缺血性卒中的独立危险因素,并且对LAA型影响更为明显。
[Abstract]:Objective to analyze the expression and significance of serum cystatin C (Cys-C) in patients with acute ischemic stroke and the ischemic stroke subtype (CISS) in China. Methods 200 cases of acute ischemic stroke hospitalized in the Department of Neurology of Second Hospital Affiliated to Lanzhou University from August 2014 to April 2015 were included as the observation group, and the healthy physical examination was selected for the same period. 136 patients with non cerebral vascular disease in the hospital were used as the control group. According to the CISS classification standard, the etiology of ischemic stroke patients was classified and the serum Cys-C level of all patients was detected. The relationship between ischemic stroke and its subtype and Cys-C level was analyzed by multi factor unconditional Logistic regression. Results (1) the patients in the observation group and their large scale were found. Atherosclerotic (LAA), cardiac apoplexy (CS), and perforator artery disease (PAD) subgroup were higher than the control group (1.06 + 0.25), (1.12 + 0.23), (1.17 + 0.42), (1.01 + 0.21) mg/L ratio (0.94 + 0.16) mg/L, P 0.05); (2) the serum Cys-C level in the LAA subgroup was higher than that of the PAD subgroup (P? 0.05); (3) Logistic regression analysis results It was shown that high level serum Cys-C was a risk factor for ischemic stroke (OR=19.148,95%CI:3.814~96.133, P? 0.001). After combining the observation group with the control group, the five quantiles were divided according to the serum level of Cys-C, and the highest number of Cys-C levels in the five digits was significantly affected by the other factors (OR=4.461,95%CI:1.599~12. 443, P0.05), and when the level of serum Cys-C was in the highest five digits, the effect on type LAA was more obvious (OR=7.075,95%CI:1.883~26.589, P=0.004). Conclusion the increase of serum Cys-C level may be an independent risk factor for ischemic stroke, and the effect on LAA type is more obvious.

【作者单位】：兰州大学第二医院神经内科;
【基金】：兰州科技计划项目(2011-1-134)
【分类号】：R743.3

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