心胸外科铜绿假单胞菌的传播机制及耐药性

发布时间：2018-05-11 01:38

本文选题：铜绿假单胞菌 + 心胸外科　；参考：《实用医学杂志》2016年07期

【摘要】：目的:探讨心胸外科铜绿假单胞菌(PA)的传播机制及耐药性。方法:采用ERIC-PCR和接合转移试验分析PA的传播途径;应用琼脂稀释法检测PA药物敏感性。结果:检测到76种基因图谱,其中有两种类型分别有12株(A型)和18株(B型)。接合转移试验的阳性率为79.41%(54株),可以传播部分耐药性的PA占92.59%(50株),其中参与接合转移试验的A型PA(8株)和B型PA(12株)均100%试验阳性并分别100%(8株)和83.33%(10株)传播部分耐药性。A型和B型均可以感染多个部位,均以感染呼吸道最为常见(分别66.67%和44.44%)。头孢唑林的耐药率为100.00%,其他抗菌药物均有不同程度的耐药性。A型PA对头孢他啶等耐药率明显高于其他基因图谱型PA。结论:PA耐药形势严峻,并可感染多个部位,同时存在垂直传播的现象和拥有水平传播的潜力。
[Abstract]:Objective: to investigate the transmission mechanism and drug resistance of Pseudomonas aeruginosa in cardiothoracic surgery. Methods: the transmission route of PA was analyzed by ERIC-PCR and conjugation transfer test, and the drug sensitivity of PA was detected by Agar dilution method. Results: 76 genotypes were detected, of which 12 were type A and 18 were type B, respectively. The positive rate of the conjugate transfer test was 79.41 and 54 strains, and the percentage of PA that could spread partial drug resistance was 92.599.59%, of which the type A PA(8 strains and B type PA(12 strains participating in the conjugation transfer test were both 100% positive and 100%) and 83.33% (10 strains) respectively. Drug resistance. Type A and B can infect multiple sites. Respiratory tract infection was the most common (66.67% and 44.44% respectively). The resistance rate of cefazolin to ceftazidime was 100.00.The resistance rate of other antimicrobial agents to ceftazidime was significantly higher than that of other genotypes. Conclusion the drug resistance of 10% PA is severe, and it can infect many parts. There exists the phenomenon of vertical transmission and the potential of horizontal transmission at the same time.
【作者单位】：海南医学院附属医院心胸外科;
【分类号】：R655

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