血清PCT对MODS早期诊断价值的meta分析

发布时间：2018-05-11 19:45

本文选题：降钙素原 + 多器官功能障碍综合征　；参考：《重庆医科大学》2013年硕士论文

【摘要】：背景：多器官功能障碍综合征(multiple organ dysfunctionsyndrome，MODS)是严重创伤、严重感染患者的常见并发症，病死率较高。MODS患者的早期诊断对患者的预后至关重要。国内外学者研究了血清清降钙素原（Procalcitonin, PCT）在严重创伤致MODS患者中的变化，，并对其早期诊断的临床应用价值进行了探讨。目的：对血清PCT用于早期诊断MODS的价值进行系统性评价。方法：计算机检索PubMed、ISLBPMEDLINE数据库、Springlink数据库、万方数据知识服务平台、中国知网、中国生物医学文献数据库和维普中文科技期刊数据库。检索年限为1990年1月至2012年3月。收集相关的原始研究文献，并通过阅读摘要及全文分析，根据纳入条件进行筛选。通过QUADAS质量评价标准评估纳入文献质量。使用Review Manger5.14软件对纳入文献的数据做连续性变量的加权平均数差（WMD）、标准化平均数差（SMD）以及95%置信区间（CI）分析，并绘制漏斗图以判断偏倚。结果：（1）共检索出相关英文文献27篇，中文文献26篇。（2）通过阅读标题、摘要和全文，严格按照纳入标准，最终获取文献9篇，其中英文文献3篇，中文文献6篇。（3）对纳入文献使用Review Manger5.14软件进行分析，其WMD分析结果以及95%CI(置信区间)分别为为4.22（2.845.61）。（4）对纳入文献使用Review Manger5.14软件进行分析，其SMD分析结果以及95%CI分别为1.79（0.902.68）。结论：PCT对MODS的早期诊断有应用价值，且在并发多MODS患者入院后24小时即可检测，可作为早期预测MODS的独立指标。
[Abstract]:Background: multiple organ dysfunctional syndrome (mods) is a common complication in patients with severe trauma and severe infection. The early diagnosis of multiple organ dysfunction syndrome (mods) is very important to the prognosis of patients with mods. The changes of Procalcitonin (PCT) in patients with MODS caused by severe trauma were studied, and the clinical value of its early diagnosis was discussed. Objective: to evaluate the value of serum PCT in early diagnosis of MODS. Methods: a computer-based search was conducted on the PubMedine ISLBPMEDLINE database, the Springlink database, the Wanfang data knowledge Service platform, the China knowledge Network, the Chinese Biomedical Literature Database and the Weipu Chinese Science and Technology Journal Database. The retrieval period is from January 1990 to March 2012. Collect relevant original research documents and select according to inclusion condition by reading abstract and full text analysis. Literature quality is included through QUADAS quality evaluation criteria. The Review Manger5.14 software is used to analyze the weighted mean difference of the continuity variable, the standardized average difference and the 95% confidence interval (CI), and to draw the funnel diagram to judge the bias. Results: A total of 27 English and 26 Chinese literatures were found. (2) by reading the title, abstract and full text, according to the inclusion criteria, 9 papers were obtained, of which 3 were in Chinese and English, and 6 in Chinese. The results of WMD analysis and 95 CI (confidence interval) are 4.22 / 2.845.61 respectively. The results of SMD analysis and 95%CI were 1.790.902.68 and 1.790.902.68 respectively. Conclusion it is valuable for early diagnosis of MODS and can be detected 24 hours after admission in patients with multiple MODS. It can be used as an independent index for early prediction of MODS.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R459.7

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