ABO血型与急性心肌梗死患者梗死相关动脉自发再通的相关性研究

发布时间：2018-05-12 05:44

本文选题：ABO血型系统 + 心肌梗死　；参考：《中国循环杂志》2017年06期

【摘要】：目的:探讨ABO血型与急性心肌梗死(AMI)患者梗死相关动脉自发再通的相关性。方法:连续入选1 209例AMI患者,根据心肌梗死溶栓治疗临床试验(TIMI)血流程度将患者分为非自发再通组(TIMI 0~1级,n=442)和自发再通组(TIMI 2~3级,n=767),分析研究ABO血型与自发再通发生的关系。结果:本研究显示,与非自发再通组相比,自发再通组中O型血较常见(32.3%vs 24.7%),A型血者较为少见(31.7%vs 24.9%)。同时,我们发现O型血患者的致动脉粥样硬化性胆固醇包括总胆固醇和低密度脂蛋白胆固醇明显低于非O型血患者(P0.05)。多因素回归分析表明,校正年龄、性别、体重指数、高血压、糖尿病、吸烟、低密度脂蛋白胆固醇及C反应蛋白、血沉、纤维蛋白原、D-二聚体、内皮心肌功能等因素后,O型血可独立预测AMI患者自发再通的发生[比值比(OR)=1.49,95%可信区间(CI):1.10~2.05)],A型血则不利于自发再通的发生(OR=0.65,95%CI:0.48~0.80)。结论:ABO血型与AMI患者自发再通的发生有关。其中,O型血有利于患者自发再通的发生,而A型血不利于自发再通的发生。
[Abstract]:Objective: to investigate the relationship between ABO blood group and spontaneous recanalization of infarct-related arteries in patients with acute myocardial infarction (AMI). Methods: 1 209 consecutive patients with AMI were selected. According to the degree of thrombolytic therapy, the patients were divided into non-spontaneous recanalization group and spontaneous recanalization group. The relationship between ABO blood group and spontaneous recanalization was studied. Results: compared with non-spontaneous recanalization group, type O blood was more common in spontaneous recanalization group than in type A blood group (32.3vs 24.7A). 31.7% vs 24.9C was less common in spontaneous recanalization group than in non-spontaneous recanalization group. At the same time, we found that Atherosclerotic cholesterol including total cholesterol and low density lipoprotein cholesterol in patients with type O blood were significantly lower than those in patients with non-O type blood. Multivariate regression analysis showed that adjusted age, sex, body mass index, hypertension, diabetes, smoking, low density lipoprotein cholesterol and C-reactive protein, erythrocyte sedimentation rate, fibrinogen D-dimer, Type O blood can independently predict spontaneous recanalization in patients with AMI (ratio of 1.49% 95% CI = 1.1010 / 2.05), but type A blood is not conducive to spontaneous recanalization (0.65% 95% CI: 0.48% 0.80%). Conclusion\ Type O blood is conducive to spontaneous recanalization, while type A blood is not conducive to spontaneous recanalization.
【作者单位】：北京协和医学院中国医学科学院国家心血管病中心阜外医院心血管疾病国家重点实验室血脂异常与心血管病诊治中心;南京军区福州总医院心内科;
【分类号】：R542.22

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