应用TCD评价经典双抗治疗对急性脑梗死患者脑血管储备功能的影响

发布时间：2018-05-15 20:08

本文选题：脑梗死 + 双抗治疗　；参考：《中国老年学杂志》2017年21期

【摘要】：目的探讨阿司匹林联合氯吡格雷双抗治疗对急性脑梗死患者神经功能缺损及脑血管反应性的影响。方法观察130例发病24 h内急性脑梗死患者,分为观察组和对照组,观察组给予阿司匹林联合氯吡格雷,对照组给予阿司匹林,分别于治疗前,治疗后3、6、12个月进行神经功能缺损程度评分,并于治疗前,治疗后12个月进行脑血管反应性检测。结果观察组脑梗死患者较对照组3个月神经缺损评分改善(P0.05);6、12个月相比无明显差异(P0.05)。观察组进展性脑卒中患者3、6、12个月神经功能缺损评分均较对照组明显改善(P0.05)。治疗12个月后观察组脑血管反应性均较对照组明显改善(P0.05)。结论阿司匹林联合氯吡格雷双重抗血小板治疗可有效改善脑梗死患者神经功能缺损程度,且能够有效改变其脑血管反应性,从而有效预防脑卒中的再次发生。
[Abstract]:Objective to investigate the effect of aspirin combined with clopidogrel on the nerve function defect and cerebrovascular reactivity in patients with acute cerebral infarction. Methods 130 patients with acute cerebral infarction in 24 h were observed and divided into observation group and control group. The observation group was given aspirin combined with clopidol Gray, and the control group was given aspirin, respectively. Before the treatment, the degree of nerve function defect was scored at 3,6,12 months after treatment, and the cerebrovascular reactivity was detected 12 months after treatment. The results of cerebral infarction in the observation group were improved (P0.05) compared with the control group (P0.05), and there was no significant difference in 6,12 months (P0.05). The 3,6,12 month nerve of the progressive stroke patients in the observation group The cerebral vascular reactivity of the observation group was significantly improved after 12 months of treatment (P0.05). Conclusion the double antiplatelet therapy with clopidogrel combined with aspirin can effectively improve the degree of neural function defect in patients with cerebral infarction and can effectively change the cerebrovascular reactivity of cerebral infarction. It can prevent the recurrence of cerebral apoplexy.

【作者单位】：吉林省人民医院神经内科;吉林大学中日联谊医院神经内科;
【基金】：吉林省卫生厅课题(No.20122C014)
【分类号】：R743.33

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