消栓肠溶胶囊联合阿加曲班对急性脑梗死患者血流变及内皮功能的影响

发布时间：2018-05-17 23:37

本文选题：消栓肠溶胶囊 + 阿加曲班　；参考：《中华中医药学刊》2016年09期

【摘要】：目的:观察消栓肠溶胶囊对急性脑梗死患者血流变及血管内皮功能的影响。方法:将纳入标准的105例急性脑梗死患者按照随机数字表法分为治疗组(52例)和对照组(53例),其中治疗组给予消栓肠溶胶囊、阿加曲班治疗,对照组给予阿加曲班治疗,两组患者均治疗4周,12周随访。观察两组患者治疗前、后症状体征,检测治疗前后血流变学指标,检测治疗前、中、后及12周随访内皮祖细胞数量及血管内皮活性物质含量,观察记录两组患者的不良反应。结果:治疗组总有效率为90.38%,对照组总有效率为77.35%,两组疗效比较差异明显。治疗后治疗组全血黏度(高切、中切、低切)均较前下降,对照组全血黏度(高切、低切)均较前下降,中切治疗前后无明显差异;两组血浆黏度值、HCT均较前下降,治疗组效果更为明显;治疗组FIB较前明显下降,差异具有明显统计学意义(P0.01),对照组FIB较前下降,差异具有统计学意义(P0.05),组间差异具有统计学意义(P0.05)。两组EPCs在72 h、14 d前均呈持续上升趋势,而治疗组上升尤为明显;治疗后均有所回落,较治疗前仍存在差异,并且治疗组EPCs明显高于对照组;12周随访,治疗较前仍显著下降,对照组较前无明显差异。治疗组NO、e NOS治疗后上升,12周随访下降,对照组NO治疗后较前无明显差异,随访较前下降明显,两组治疗方法对NO、e NOS影响具有明显差异。结论:治疗组临床疗效明显优于对照组,可显著降低血液黏滞度,改善血流及微循环,消栓肠溶胶囊可能通过促进EPCs增殖,提高血管内皮活性物质分泌量治疗ACI。
[Abstract]:Objective: To observe the effect of shuishuan enteric capsule on blood rheology and vascular endothelial function of patients with acute cerebral infarction. Methods: 105 patients with acute cerebral infarction were divided into treatment group (52 cases) and control group (53 cases) according to the random digital table method. The treatment group was treated with thrombus enteric capsule, adagadan, and the control group was given adagadan Treatment, two groups of patients were treated for 4 weeks and 12 weeks of follow-up. Observe the symptoms and signs of the two groups before and after treatment, detect the hemorrheology indexes before and after treatment, detect the number of endothelial progenitor cells and the content of vascular endothelial active substances before, during and after treatment, and observe the adverse reactions of the two groups of patients before and after treatment. The results: the total effective rate of the treatment group was 90.38%, and the results were 90.38%, and the results were 90.38%. The total effective rate of the group was 77.35%. The curative effect of the two groups was significantly different. The whole blood viscosity (high cut, middle cut, low cut) of the treatment group was lower than that of the former, and the whole blood viscosity (high cut, low cut) in the control group was lower than that of the former, and there was no obvious difference before and after the treatment. The plasma viscosity value of the two groups was lower than that of the former, and the effect of the treatment group was more obvious; the treatment group was more than the treatment group, and the treatment group FIB was more than the treatment group. The difference has significant statistical significance (P0.01), the control group FIB decreased compared with the previous, the difference has statistical significance (P0.05), the difference between groups has statistical significance (P0.05). The two groups of EPCs in 72 h, 14 d before the continuous upward trend, and the treatment group is especially obvious; after treatment, there is a decline, and there are still different than before treatment, and The treatment group EPCs was significantly higher than the control group, 12 weeks follow-up, the treatment was still significantly decreased, the control group had no significant difference compared with the former. The treatment group NO, e NOS after treatment increased, 12 weeks follow-up decreased, the control group after NO treatment compared with the previous significant difference, the two groups of treatment methods on NO, e NOS have significant differences. Conclusion: treatment group is the clinical difference. Conclusion: treatment group is the clinical difference. The effect of bed is obviously better than that of the control group, which can significantly reduce the blood viscosity and improve the blood flow and microcirculation. The suppository enteric capsule may improve the proliferation of EPCs and increase the secretion of vascular endothelial active substance to treat ACI.
【作者单位】：淄博第一医院;黑龙江中医药科学院南岗分院;
【基金】：黑龙江省中医药管理局科研基金项目(CZ14-39)
【分类号】：R743.3

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