左西孟坦注射液联合无创呼吸机治疗老年急性心力衰竭的临床研究

发布时间：2018-05-18 03:04

本文选题：左西孟坦注射液 + 无创呼吸机　；参考：《中国临床药理学杂志》2017年12期

【摘要】：目的观察左西孟坦注射液联合无创呼吸机治疗老年急性心力衰竭的临床疗效及安全性。方法将162例老年急性心力衰竭患者随机分为对照组81例和试验组81例。2组患者均予以无创呼吸机治疗。在此基础上,对照组予以盐酸多巴酚丁胺注射液5μg·kg~(-1)·min~(-1),维持静脉泵注24 h;试验组予以左西孟坦注射液12μg·kg~(-1)静脉泵注10 min后,改为0.1μg·kg~(-1)·min~(-1)维持泵注24 h。2组患者均治疗24 h。比较2组患者的临床疗效、心输出量(CO)、心脏指数(CI)、心率,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为96.29%(78/81例)和86.42%(70/81例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的CO分别为(2.33±0.33)和(1.79±0.24)L·min~(-1),CI分别为(3.23±0.46)和(2.35±0.32)L·min~(-1)·m~(-2),心率分别为(97.65±13.27)和(112.12±10.89)次/分,差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有头晕、血压下降和胃肠胀气,对照组的药物不良反应主要有头晕和胃肠胀气。试验组和对照组的药物不良反应发生率分别为13.58%和11.11%,差异无统计学意义(P0.05)。结论左西孟坦注射液联合无创呼吸机治疗急性老年心力衰竭的临床疗效确切,其可显著降低患者的心率,提高CO、CI水平,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of levsimentan injection combined with non-invasive ventilator in the treatment of elderly patients with acute heart failure. Methods 162 elderly patients with acute heart failure were randomly divided into control group (81 cases) and experimental group (81 cases). On this basis, the control group was treated with dobutamine hydrochloride injection 5 渭 g / kg 路min ~ (-1) for 24 h, while the control group was treated with levsimentan injection (12 渭 g / kg) for 10 min and then changed to 0.1 渭 g 路kg ~ (-1) 路min ~ (-1) 路min ~ (-1). The clinical efficacy, cardiac output, cardiac index, heart rate and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 96.29 / 78 / 81 and 86.42 / 70 / 81, respectively. The difference was statistically significant (P 0.05). After treatment, the CO values of the experimental group and the control group were 2.33 卤0.33) and 1.79 卤0.24 L / min respectively, the CI were 3.23 卤0.46) and 2.35 卤0.32 L / min respectively. The heart rate was 97.65 卤13.27 and 112.12 卤10.89 / min, respectively. The main adverse drug reactions in the test group were dizziness, decreased blood pressure and flatulence, while in the control group the main adverse drug reactions were dizziness and flatulence. The incidence of adverse drug reactions in the test group and the control group were 13.58% and 11.11%, respectively, with no significant difference (P 0.05). Conclusion the clinical effect of levoximentam injection combined with noninvasive ventilator in the treatment of acute senile heart failure is definite. It can significantly reduce the heart rate, increase the level of COOCI, and do not increase the incidence of adverse drug reactions.
【作者单位】：郑州大学附属医院南阳市中心医院重症医学科;郑州大学附属医院南阳市中心医院内分泌科;郑州大学附属医院南阳市中心医院消化科;
【基金】：河南省医学科技攻关计划基金资助项目(122300410028)
【分类号】：R541.6

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