老年脓毒症患者降钙素原、胆碱酯酶及肌钙蛋白I水平变化与其生存状况的关系

发布时间：2018-05-23 23:49

本文选题：脓毒症 + 降钙素原　；参考：《中国老年学杂志》2017年22期

【摘要】：目的探讨老年脓毒症患者降钙素原、胆碱酯酶及肌钙蛋白I水平变化与其生存状况的关系。方法老年脓毒症患者100例,按照病情严重程度分为3组,对照组为一般脓毒症患者50例,重症组为严重脓毒症患者30例,休克组为脓毒症休克患者20例;按照预后情况将重症、休克组分为存活组(n=35)和死亡组(n=15)。分析所有患者血清降钙素原、胆碱酯酶及肌钙蛋白I水平变化及与急性生理与慢性健康状况评分(APACHEⅡ)的关系。结果 3组血清降钙素原、胆碱酯酶及肌钙蛋白I水平比较差异有统计学意义(P0.05),其中血清降钙素原、肌钙蛋白I水平对照组均最低,休克组最高,而胆碱酯酶水平对照组最高,休克组最低;存活组血清降钙素原及肌钙蛋白I水平、APACHEⅡ评分均低于死亡组,而胆碱酯酶水平高于死亡组(P0.05);Pearson相关性分析显示,血清降钙素原及肌钙蛋白I水平与APACHEⅡ评分呈正相关(r=0.423,0.326,均P0.05),胆碱酯酶与APACHEⅡ评分呈负相关(r=-0.341,P0.05)。结论降钙素原、胆碱酯酶及肌钙蛋白I水平与老年脓毒症患者的病情及预后有关,可有效反映患者病情严重程度,检测上述因子水平有利于医师进一步了解患者的病情和判断预后,进而实施有针对性的治疗措施。
[Abstract]:Objective to investigate the relationship between the changes of calcitonin, cholinesterase and troponin I in elderly patients with sepsis. Methods 100 cases of senile sepsis were divided into 3 groups according to the severity of the disease. The control group was 50 cases of general sepsis, 30 cases with severe sepsis and 20 cases of septic shock. According to the prognosis, the shock group was divided into the survival group (n=35) and the death group (n=15). The changes in serum calcitonin, cholinesterase, troponin I and the acute physiological and chronic health status score (APACHE II) were analyzed in all patients. Results the serum calcitonin, cholinesterase and troponin I levels in the 3 groups were compared. There were statistical significance (P0.05), in which serum calcitonin and troponin I were the lowest in the control group, the highest in the shock group, the highest in the cholinesterase control group and the lowest in the shock group. The serum calcitonin and the troponin I level in the survival group were lower than those in the dead group, and the level of the cholinesterase was higher than that in the death group (P0.05); the Pearson related level was related to the death group (P0.05). The sex analysis showed that serum calcitonin and troponin I were positively correlated with APACHE II score (r=0.423,0.326, P0.05), and cholinesterase and APACHE II score were negatively correlated (r=-0.341, P0.05). Conclusion calcitonin, cholinesterase and troponin I levels were related to the condition and prognosis of the elderly patients with sepsis, which could effectively reflect the patient's condition. Severity, detection of these factors is conducive to further understanding of the patient's condition and prognosis, and then to implement targeted treatment measures.
【作者单位】：南通大学附属医院;
【分类号】：R459.7

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