脉络宁注射液辅助治疗急性脑梗死的临床观察

发布时间：2018-05-25 05:08

本文选题：脉络宁注射液 + 急性脑梗死　；参考：《中国药房》2017年20期

【摘要】：目的:观察脉络宁注射液辅助治疗急性脑梗死的临床疗效及安全性。方法:选择在我院神经内科确诊的65例急性脑梗死患者作为研究对象,按随机数字表法分为对照组(32例)和观察组(33例)。对照组患者给予常规基础治疗,观察组患者在对照组基础上加用脉络宁注射液10 m L加入0.9%氯化钠注射液250 m L中,ivgtt,qd。两组患者疗程均为15 d。比较两组患者临床疗效及治疗前后血清氧化低密度脂蛋白(ox-LDL)、脑钠肽(BNP)、基质金属蛋白酶9(MMP-9)水平和美国国立卫生研究院卒中量表(NIHSS)评分以及治疗过程中不良反应发生情况。结果:观察组的有效率为90.91%,显著高于对照组的65.63%,差异有统计学意义(P0.05)。治疗前,两组患者血清ox-LDL、BNP及MMP-9水平和NIHSS评分比较,差异均无统计学意义(P0.05);治疗后,两组患者血清ox-LDL、BNP及MMP-9水平和NIHSS评分均显著降低,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P0.05)。结论:脉络宁注射液辅助治疗急性脑梗死疗效显著,能明显降低患者血清ox-LDL、BNP及MMP-9水平,改善神经功能促进脑梗死患者的恢复,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of Mailuoning injection in the treatment of acute cerebral infarction. Methods: Sixty-five patients with acute cerebral infarction diagnosed in neurology department in our hospital were divided into control group (n = 32) and observation group (n = 33). The patients in the control group were treated with routine basic therapy, the patients in the observation group were treated with Mailuoning injection 10 mL plus 0.9% sodium chloride injection 250 mL in the observation group. The course of treatment was 15 days in both groups. The clinical efficacy, serum levels of oxidized low density lipoprotein (ox-LDL), brain natriuretic peptide (BNPN), matrix metalloproteinase-9 (MMP-9), NIHSS scores and adverse reactions during treatment were compared between the two groups. Results: the effective rate of the observation group was 90.91, which was significantly higher than that of the control group (65.63), the difference being statistically significant (P 0.05). Before treatment, there was no significant difference in serum ox-LDL MMP-9 levels and NIHSS scores between the two groups. After treatment, the levels of serum ox-LDLL-BNP, MMP-9 and NIHSS scores in the two groups were significantly lower than those in the control group, and those in the observation group were significantly lower than those in the control group. The difference was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Mailuoning injection is effective in the treatment of acute cerebral infarction. It can obviously reduce the level of serum ox-LDL and MMP-9 and improve the nerve function to promote the recovery of cerebral infarction patients. The safety of Mailuoning injection is good.
【作者单位】：唐山市工人医院神经外科;唐山市食品药品检验中心;
【分类号】：R743.33

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