缺血适应对急性脑梗死患者NIHSS评分及血清CysC水平的影响及相关性

发布时间：2018-05-28 09:29

本文选题：急性脑梗死 + 缺血适应　；参考：《中国老年学杂志》2016年04期

【摘要】：目的探讨缺血适应对急性脑梗死患者美国国立卫生研究院卒中量表(NIHSS)评分及血清胱抑素C(Cys C)水平的影响,并分析NIHSS与Cys C水平的相关性。方法选取2012年3月至2014年12月就诊的急性脑梗死患者82例,按数字表法随机分为观察组、对照组,对照组患者接受常规治疗,观察组患者在对照组基础上行肢体缺血适应训练,连续治疗6个月;记录患者治疗前后NIHSS评分与Cys C、CRP水平变化,采用Spearman相关分析NIHSS评分与Cys C相关性。结果治疗后观察组症状改善(82.93%)显著高于对照组(63.41%)(χ2=3.975 8,P0.05),脑血流及代谢改善(80.49%)明显高于对照组(46.34%)(χ2=10.302 6,P0.05),脑梗死体积缩小(58.54%)显著高于对照组(36.59%)(χ2=3.960 6,P0.05),治疗后MRI复检,观察组新发脑梗死者(2.44%)显著低于对照组(14.63%)(χ2=3.975 8,P0.05);与治疗前比较,两组治疗后NIHSS评分、Cys C、CRP水平均显著降低(P0.05);且治疗后观察组显著低于对照组(P0.05);患者NIHSS评分与血清Cys C水平呈正相关(r=0.579,P=0.00)。结论 Cys C水平与急性脑梗死病情相关,缺血适应训练可改善急性脑梗死患者神经功能症状及脑血流,降低患者血清Cys C水平,有利于预防再发脑梗死。
[Abstract]:Objective to investigate the effects of ischemic adaptation on the NIHSS score and serum cystatin C(Cys C level in patients with acute cerebral infarction (ACI), and to analyze the correlation between NIHSS and Cys C levels. Methods Eighty-two patients with acute cerebral infarction from March 2012 to December 2014 were randomly divided into two groups. The patients in the control group received routine treatment. The patients in the observation group received limb ischemic adaptation training on the basis of the control group. The changes of NIHSS score and Cys C C were recorded before and after treatment for 6 months, and the correlation between NIHSS score and Cys C was analyzed by Spearman correlation analysis. Results after treatment, the symptom improvement in the observation group was significantly higher than that in the control group (63.41) (蠂 ~ 2 ~ 2 ~ (3.975) ~ 80.49) and the improvement of cerebral blood flow and metabolism was significantly higher than that in the control group (蠂 ~ (2 +) 10.302 ~ (6) U P 0.05, P ~ (0.05) and 36.59 ~ (th) (蠂 ~ 2 ~ (2) 3.960 ~ (6) P _ (0.05). After treatment, MRI was re-examined. The level of NIHSS score was significantly lower in the observation group than that in the control group (蠂 2, 3.975 8, P 0.05, compared with before treatment), and was significantly lower in the observation group than that in the control group after treatment, and was significantly lower in the observation group than in the control group after treatment, and there was a positive correlation between the NIHSS score and the level of serum Cys C in the observation group. Conclusion the level of Cys C is related to the condition of acute cerebral infarction. Ischemic adaptation training can improve the neurological function and cerebral blood flow of patients with acute cerebral infarction, decrease the level of serum Cys C, and help to prevent recurrent cerebral infarction.
【作者单位】：安徽医科大学;安徽省第二人民医院神经内科;
【分类号】：R743.3

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