急性脑梗死患者血脂水平与脑微出血的相关性

发布时间：2018-05-29 02:51

  本文选题：脑微出血 + 危险因素　； 参考：《安徽医科大学》2013年硕士论文

【摘要】：目的：应用MRI磁敏感加权成像（SWI）序列对急性脑梗死患者伴发脑微出血（CMBs）状况进行检测，探讨急性脑梗死患者血脂水平与脑微出血的相关性。 资料和方法： 一般资料：选择我院2012年1月~2012年12月连续收治的104例急性脑梗死患者，根据MRI磁敏感加权成像（SWI）上有无CMBs分为2组，CMBs组48例和无CMBs组56例。比较两组患者的一般临床资料及生化指标是否存在差异，并进一步回归分析CMBs发生的相关危险因素。 设备及检查方法：本研究利用德国Siemens1.5T超导型磁共振，型号为AvantoⅠclass，支持行SWI检查所需的软件。所有入组患者均行常规自旋回波（SE）序列T1加权成像T1WI、T2加权成像T2WI、液体衰减反转恢复FLAIR、弥散加权成像DWI及SWI检查。记录SWI序列上CMBs的出现例数、数目、部位。利用横断面分析方法对CMBs危险因素进行分析。根据有无CMBs进行分组，分组后比较两组患者的人口学资料、既往病史、入院前服药情况、实验室检查等指标，进一步回归分析CMBs发生的相关危险因素。 图像评价：所得图像由磁共振室及神经科经验丰富的医师阅片，同时参考CMBs观察者量表（BOMBS）以提高不同研究者之间的一致性；经协商一致后，记录CMBs的数目及分布。 统计学数据处理：所有数据利用SPSS13.0统计软件包进行处理。采用单因素分析对CMBs可疑危险因素进行筛选。以有无CMBs为因变量，将P＜0.05的相关因素作为自变量，进行逐步logistic回归分析，，结果以P＜0.05为差异有统计学意义。 结果：1.两组在年龄、性别、既往病史等一般资料比较差异无统计学意义（P＞0.05）。 2.与无CMBs组比较，CMBs组TC、TG明显降低，差异有统计学意义（P＜0.01，P＜0.05）。2组其他生化指标差异无统计学意义（P＞0.05）。 3.以有无CMBs为因变量，以TC、TG为自变量进行Logistic回归分析， TC为CMBs的独立危险因素。结论：CMBs在急性脑梗死患者中患病率较高，血清TC是CMBs的独立危险因素。
[Abstract]:Objective: to detect the status of cerebral microhemorrhage (CMBs) in patients with acute cerebral infarction by using MRI magnetic sensitive weighted imaging (SWI) sequence, and to explore the correlation between blood lipid level and cerebral microhemorrhage in patients with acute cerebral infarction.
Information and methods:
General data: 104 cases of acute cerebral infarction were selected in our hospital in December ~2012 January 2012. According to MRI magnetic sensitive weighted imaging (SWI), there were 2 groups, 48 cases in group CMBs and 56 cases without CMBs. Compare the difference between the general clinical data and biochemical indexes of the two groups, and further regression analysis of the phase of the occurrence of CMBs. Close the risk factors.
Equipment and methods of examination: This study uses the German Siemens1.5T superconducting magnetic resonance (Avanto I class) to support the software required for the SWI examination. All the patients who enter the group do the normal spin echo (SE) sequence T1 weighted imaging T1WI, T2 weighted imaging T2WI, liquid attenuation reversal FLAIR, diffusion-weighted imaging DWI and SWI examination. The number, number and location of CMBs were analyzed. The risk factors of CMBs were analyzed by cross section analysis. According to or without CMBs, the demographic data of the two groups, the past medical history, the medication situation before admission, and the laboratory examination were compared, and the related risk factors of CMBs were analyzed.
Image evaluation: the images were read by the experienced physicians of the magnetic resonance chamber and the neurology department, and the CMBs observer scale (BOMBS) was used to improve the consistency between the different researchers. After consensus, the number and distribution of CMBs were recorded.
Statistical data processing: all data were processed using SPSS13.0 statistical software package. Single factor analysis was used to screen suspicious risk factors of CMBs. With or without CMBs as the dependent variable, the relative factors of P < 0.05 were used as independent variables, and the logistic regression analysis was carried out. The results were statistically significant with the difference of P < 0.05.
Results: 1. there was no significant difference in age, sex and past medical history between the two groups (P > 0.05).
2. compared with group CMBs, TC and TG in group CMBs were significantly lower than those in group TC (P < 0.01, P < 0.05). There was no significant difference in other biochemical indexes in.2 group (P > 0.05).
3. take CMBs as dependent variable and TC and TG as independent variables to make Logistic regression analysis.
TC is an independent risk factor for CMBs. Conclusion: the prevalence of CMBs is high in patients with acute cerebral infarction. Serum TC is an independent risk factor for CMBs.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R743.33

【参考文献】

相关期刊论文 前1条

1 王本国;林棉;杨楠;刘树学;陆兵勋;潘速跃;;不同脑血管病患者脑微出血的患病率及其危险因素分析[J];中国神经精神疾病杂志;2011年05期

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