不同压力高压氧治疗的弥漫性轴索损伤患者定量脑电图脑电波相对功率变化及其意义

发布时间：2018-05-29 16:38

本文选题：弥漫性轴索损伤 + 高压氧治疗　；参考：《山东医药》2016年43期

【摘要】：目的观察接受不同压力高压氧治疗的弥漫性轴索损伤(DAI)患者定量脑电图(q EEG)脑电波相对功率的变化,并探讨其意义。方法 DAI患者50例,随机分为对照组(10例)、0.20 MPa组(20例)和0.25 MPa组(20例)。各组常规治疗相同,0.20 MPa组在常规治疗的基础上给予压力为0.20 MPa的高压氧治疗、0.25 MPa组在常规治疗的基础上给予压力为0.25 MPa的高压氧治疗,1次/d,10次为1个疗程,连续3个疗程。各组患者分别于入院后第1天(治疗前)及0.20 MPa组、0.25 MPa组高压氧治疗3个疗程结束后(治疗后)进行q EEG检查,分析不同采样点的δ波(0.5~3 Hz)、θ波(4~7 Hz)、α波(8~13 Hz)、β波(14~40 Hz)频率,计算各采样点脑电波的相对功率即慢波(δ、θ波)频率之和(δ+θ)与快波(α、β波)频率之和(α+β)的比值。高压氧开始治疗后6个月进行GOS评分。结果治疗后,各组不同采样点脑电波的相对功率均较治疗前减小(P均0.05),0.25 MPa组与0.20 MPa组和对照组相比,P均0.05。高压氧开始治疗后6个月,GOS评分0.25 MPa组0.20 MPa组对照组,组间相比,P均0.05;且各组脑电波相对功率与GOS评分均呈负相关(0.25 MPa组、0.20 MPa组、对照组的rs分别为0.856、0.863、0.935,P均0.01)。结论对于DAI患者,与早期0.20 MPa高压氧治疗相比,0.25 MPa高压氧治疗可以加快患者脑电波慢波减少或快波增多的进程。对DAI患者实施高压氧治疗时选择0.25 MPa的压力,其脑功能恢复更快。观察DAI患者脑电波相对功率的变化将有助于其预后的判断。
[Abstract]:Objective to observe the changes of brain wave relative power in patients with diffuse axonal injury (Dai) treated with different pressure and hyperbaric oxygen (HBO), and to explore its significance. Methods Fifty patients with DAI were randomly divided into control group (n = 10) and 0. 20 MPa group (n = 20) and 0.25 MPa group (n = 20). The group of 0. 20 MPa was treated with hyperbaric oxygen with pressure of 0. 20 MPa on the basis of routine treatment. The group of 0. 25 MPa was given 10 times of hyperbaric oxygen with pressure of 0. 25 MPa on the basis of routine treatment for 10 times as a course of treatment for 3 consecutive courses. Q EEG was performed on the first day after admission (before treatment) and 0. 20 MPa group (0. 20 MPa group) after three courses of hyperbaric oxygen therapy (after treatment). The frequency of 未 wave 0. 5HZ, 胃 wave 47 Hz, 伪 wave + 813 Hz, 尾 wave 1440 Hz) were analyzed at different sampling points. The ratio of the sum of slow wave (未, 胃 wave) frequency (未胃) to the sum of fast (伪, 尾 wave) frequency (伪尾) is calculated. GOS score was performed 6 months after hyperbaric oxygen therapy. Results after treatment, the relative power of EEG at different sampling points in each group was lower than that before treatment (P < 0.05). The relative power of brain wave in 0. 20 MPa group and 0. 20 MPa group was 0. 05% compared with 0. 20 MPa group and 0. 05% in control group. Six months after hyperbaric oxygen treatment, the scores of GOS were 0.20 MPa in the control group (P < 0.05), and there was a negative correlation between the relative power of brain wave and the GOS score in the 0.25 MPa group (0.20 MPa), the rs of the control group was 0.8560.863 卤0.935 (P < 0.01). Conclusion compared with early hyperbaric oxygen therapy of 0.20 MPa, 0.25 MPa hyperbaric oxygen therapy can accelerate the decrease of slow wave or increase of fast wave in patients with DAI. When DAI patients were given hyperbaric oxygen therapy, the recovery of brain function was faster with 0. 25 MPa pressure. Observing the change of relative power of brain wave in DAI patients will help to judge the prognosis.
【作者单位】：安徽医科大学附属解放军临床学院/中国人民解放军第105医院;
【基金】：全军医学科技“十二五”科研项目(CWS11J262) 南京军区医学科技创新重点课题(09Z009)
【分类号】：R651.15

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