急性缺血性脑卒中患者血清ox-LDL水平与颈动脉易损斑块的相关性

发布时间：2018-06-01 11:42

本文选题：缺血性脑卒中 + 氧化型低密度脂蛋白　；参考：《中国老年学杂志》2016年09期

【摘要】：目的探讨急性缺血性卒中(CIS)患者血清氧化型低密度脂蛋白(ox-LDL)水平与颈动脉易损斑块的相关性。方法选取2015年1~9月该院收治的经CT和磁共振成像(MRI)确诊为CIS患者224例,根据颈动脉B型超声检查结果将患者分为无斑块组45例、稳定斑块组62例及易损斑块组117例,调查记录研究对象的一般资料,包括血压、身高、体重等,测定血清ox-LDL、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和空腹血糖(FPG)水平;并采用颈动脉超声检测颈动脉内中膜厚度(IMT)、总斑块面积(TPA)及斑块性质,分析血清ox-LDL水平与CIS患者颈动脉易损斑块的相关性。结果三组高血压发生率、血清ox-LDL水平、颈动脉IMT平均厚度以及增厚率整体和两两比较均有显著差异(P0.05),易损斑块组的总斑块面积(TPA)明显高于稳定斑块组(P0.01)。相关性分析结果显示三组血清ox-LDL水平与血清TC、LDL-C水平以及颈动脉IMT值呈正相关(r=0.376,0.397,0.203,P0.05),与TG、HDL-C、FPG无相关性(P0.05)。Logistic回归分析结果显示易损斑块的形成仅与血清ox-LDL水平独立相关(OR=1.021,95%CI 0.996~1.072,P0.01)。结论急性CIS患者血清ox-LDL水平与颈动脉易损斑块的形成独立相关,提示ox-LDL水平可作为临床初筛易损斑块的血清学指标。
[Abstract]:Objective to investigate the relationship between serum oxidized low density lipoprotein (ox-LDL) level and carotid plaque in patients with acute ischemic stroke. Methods from January to September 2015, 224 patients with CIS were diagnosed by CT and MRI. According to the results of carotid B-mode ultrasound, the patients were divided into three groups: 45 cases without plaque, 62 cases with stable plaque and 117 cases with vulnerable plaque. The general data of the subjects were recorded, including blood pressure, height and weight. The levels of serum ox-LDL, triglyceride TGG, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FPG) were measured. Carotid intima-media thickness (IMT), total plaque area (TPA) and plaque character were measured by carotid ultrasound, and the correlation between serum ox-LDL level and carotid plaque vulnerability in CIS patients was analyzed. Results the incidence of hypertension, the level of serum ox-LDL, the average thickness of carotid IMT and the thickening rate of carotid artery were significantly different among the three groups. The total plaque area in vulnerable plaque group was significantly higher than that in stable plaque group (P 0.01). The results of correlation analysis showed that there was a positive correlation between serum ox-LDL level and serum TCL-LDL-C level and carotid IMT value in the three groups. There was no correlation between serum ox-LDL level and serum ox-LDL level. The results of logistic regression analysis showed that the formation of vulnerable plaque was only correlated with serum ox-LDL level. Conclusion the level of serum ox-LDL in patients with acute CIS is independently correlated with the formation of vulnerable plaque in carotid artery, suggesting that the level of ox-LDL can be used as a serological index for the primary sieve vulnerable plaque.
【作者单位】：河南科技大学第一附属医院超声科;
【分类号】：R743.3

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