醒脑静注射液联合高压氧对急性CO中毒患者治疗效果分析

发布时间：2018-06-02 00:44

本文选题：醒脑静注射液 + 急性CO中毒　；参考：《中成药》2017年11期

【摘要】：目的考察醒脑静注射液(麝香、栀子、郁金、冰片)联合高压氧对急性一氧化碳(CO)中毒患者治疗效果。方法选择2013年1月—2016年1月间于我院急诊科收治的74例急性CO中毒患者,随机分为两组,对照组予高压氧治疗,观察组予高压氧联合醒脑静注射液治疗,比较两组临床疗效及其对血清C反应蛋白(CRP)、谷丙转氨酶(ALT)、血肌酐(Scr)水平的影响。结果观察组患者苏醒时间、住院时间明显短于对照组,迟发性脑病发生率明显低于对照组,有效率明显高于对照组,差异均有统计学意义(P0.05)。治疗后,两组患者血清MDA、CRP及ALT、Scr均较治疗前显著下降,SOD明显上升,且观察组明显优于对照组,差异均有统计学意义(P0.05)。结论醒脑静注射液联合高压氧治疗急性CO中毒时,可清除氧自由基,抑制炎症反应,改善临床症状,减少迟发性脑病发生,保护肝肾功能,进而改善临床疗效。
[Abstract]:Objective to investigate the therapeutic effect of Xingnaojing injection (Musk, Gardenia Gardenia, Tujin, Borneol) combined with hyperbaric oxygen on acute carbon monoxide (CO) poisoning patients. Methods from January 2013 to January 2016, 74 patients with acute CO poisoning were randomly divided into two groups: control group treated with hyperbaric oxygen, observation group treated with hyperbaric oxygen combined with Xingnaojing injection. To compare the clinical efficacy of the two groups and their effects on the levels of serum C-reactive protein (CRP), alanine aminotransferase (alt) and creatinine (Cr). Results the recovery time and hospitalization time of the patients in the observation group were significantly shorter than those in the control group. The incidence of delayed encephalopathy in the observation group was significantly lower than that in the control group, and the effective rate was significantly higher than that in the control group. The difference was statistically significant (P 0.05). After treatment, the levels of serum MDA-CRP and alt SCR in the two groups were significantly lower than those before treatment, and the SOD in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). Conclusion Xingnaojing injection combined with hyperbaric oxygen therapy can eliminate oxygen free radicals, inhibit inflammatory reaction, improve clinical symptoms, reduce the occurrence of delayed encephalopathy, protect liver and kidney function, and improve the clinical efficacy.
【作者单位】：广州医科大学附属第五医院急诊科;
【基金】：广东省自然科学基金博士启动项目(10451008901004959)
【分类号】：R595.1

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