高渗氯化钠羟乙基40淀粉注射液对急性颅脑损伤患者细胞因子及神经功能预后的影响研究

发布时间：2018-06-02 13:26

本文选题：颅脑损伤 + 盐水　；参考：《中国全科医学》2017年35期

【摘要】：目的探讨高渗氯化钠羟乙基40淀粉注射液(HSH40)对急性颅脑损伤患者细胞因子及神经功能预后的影响。方法选取2014—2016年赣南医学院第一附属医院收治的急性颅脑损伤患者80例,其中轻型颅脑损伤19例,中型颅脑损伤45例,重型颅脑损伤16例。采用随机数字表法将其分为林格液组(LR组)和HSH40组,每组各40例。LR组和HSH40组分别采用林格液和HSH40复苏7 d,测定输液即刻、输液后1、3、7 d各组S100B蛋白、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)表达情况,并在6个月后行神经功能预后测定。结果轻型颅脑损伤患者:HSH40组输液后1、3、7 d S100B蛋白、MBP表达水平低于LR组,HSH40组输液后7 d NSE表达水平低于LR组(P0.05)。中型颅脑损伤患者:HSH40组输液后7 d S100B蛋白、NSE表达水平低于LR组,HSH40组输液后1、3、7 d MBP表达水平低于LR组(P0.05)。重型颅脑损伤患者:HSH40组输液后1、3、7 d S100B蛋白、MBP表达水平低于LR组,HSH40组输液后7 d NSE表达水平低于LR组(P0.05)。HSH40组神经功能预后优于LR组(χ~2=15.320,P=0.003)。结论 HSH40能够提高急性颅脑损伤患者神经功能预后,可能与降低S100B蛋白、NSE和MBP细胞因子表达有关。
[Abstract]:Objective to investigate the effect of hypertonic sodium chloride hydroxyethyl 40 starch injection (HSH40) on cytokines and neurological function in patients with acute craniocerebral injury. Methods Eighty patients with acute craniocerebral injury were selected from the first affiliated Hospital of Gannan Medical College from 2014 to 2016. Among them, 19 were mild craniocerebral injury, 45 were moderate craniocerebral injury, and 16 were severe craniocerebral injury. They were divided into two groups by random digital table method. Each group consisted of 40 cases. LR group and HSH40 group were resuscitated with Ringer solution and HSH40 for 7 days respectively. S100B protein was measured immediately after infusion and 13 days after infusion. The expression of neuron-specific enolase (NSE) and myelin basic protein (MBP) were measured after 6 months. Results the expression level of S100B protein MBP in the group of patients with mild craniocerebral injury was lower than that in group LR on the 7th day after infusion, and the expression level of NSE was lower than that in group LR on the 7th day after infusion. The expression level of S100B protein was lower in moderate craniocerebral injury group than that in LR group on the 7th day after infusion. The expression level of MBP was lower than that in LR group on the 7th day after infusion. The expression level of S100B protein MBP in the group of severe craniocerebral injury was lower than that in the group of LR group on the 7th day after infusion (P 0.05). The prognosis of nerve function in group HSH40 was better than that in group LR (蠂 2 + 15.320P0. 003). Conclusion HSH40 can improve the prognosis of neurologic function in patients with acute craniocerebral injury, which may be related to the decrease of the expression of S100B protein, NSE and MBP cytokines.
【作者单位】：江西省肿瘤医院麻醉科;赣南医学院第一附属医院麻醉科;
【基金】：江西省科技厅支撑计划(20151BBG70138)
【分类号】：R651.15

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