急性脑梗死患者血清泛素羧基末端水解酶-1和胶质纤维酸性蛋白的表达及其临床意义

发布时间：2018-06-10 01:58

本文选题：急性脑梗死 + 血清　；参考：《中南大学学报(医学版)》2017年03期

【摘要】：目的:观察急性脑梗死患者血清泛素羧基末端水解酶-1(ubiquitin C-terminal hydrolase-L1,UCH-L1)和血清胶质纤维酸性蛋白(serum glial fibrillary acidic protein,GFAP)的临床表达水平,并探讨二者对脑梗死患者的临床意义。方法:选取重庆市肿瘤医院在2014年1月至2016年2月期间收治的80例急性脑梗死患者作为观察组,另选取同时段来院做体格检查的80例健康者作为对照组。分别检测两组研究对象的血清UCH-L1和GFAP的表达水平。结果:UCH-L1诊断脑梗死的敏感度为75.0%,特异度为87.5%;GFAP诊断脑梗死的敏感度为81.3%,特异度为90.0%。UCH-L1和GFAP的受试者工作特征(receiver operating characteristic,ROC)曲线下面积分别为0.670及0.757。两组研究对象在年龄、性别、饮酒、吸烟、糖尿病、高脂血症等一般情况中比较,差异无统计学意义(P0.05);观察组患者患高血压的比例明显高于对照组(P0.05);经Spearson/Pearson分析显示血清UCH-L1与GFAP水平与高血压呈正比,与性别、年龄、糖尿病、高血脂、饮酒、吸烟等因素无相关性;观察组患者不同发病时间一般资料的比较,差异无统计学意义(P0.05),血清UCH-L1和GFAP表达水平明显高于对照组(P0.05);在不同发病时间两组患者血清UCH-L1和GFAP表达水平差异无统计学意义(P0.05);轻、中、重型3组患者的血清UCH-L1和GFAP表达水平高于对照组(P0.05);中、重型患者血清UCH-L1和GFAP表达水平高于轻型(P0.05);观察组患者在不同发病时间里血清UCH-L1和GFAP表达水平与梗死灶大小差异有统计学意义(P0.05);Pearson相关性分析结果示血清UCH-L1和GFAP表达水平呈正相关(r=0.634,P=0.001)。结论:在急性脑梗死患者中早期血清UCH-L1和GFAP的表达水平明显升高,与脑梗死的病情严重程度有一定的相关性,可为临床上早期诊断及治疗提供依据。
[Abstract]:Objective: to observe the clinical expression levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and serum glial fibrillary acidic protein (GFAP) in patients with acute cerebral infarction (ACI), and to explore their clinical significance in patients with cerebral infarction. Methods: 80 patients with acute cerebral infarction treated in Chongqing Cancer Hospital from January 2014 to February 2016 were selected as the observation group and 80 healthy persons who came to the hospital for physical examination at the same time as the control group. The levels of serum UCH-L1 and GFAP were detected. Results the sensitivity of the diagnosis of cerebral infarction was 75.0, the specificity was 87.5 and the sensitivity of the GFAP was 81.3. The area under the receiver operating characteristic ROCcurve was 0.670 and 0.7577.The specificity was 90.0.UCH-L1 and GFAP respectively. Age, sex, alcohol consumption, smoking, diabetes, hyperlipidemia were compared between the two groups. There was no significant difference between the two groups (P 0.05), the proportion of patients with hypertension in the observation group was significantly higher than that in the control group (P 0.05), and the levels of serum UCH-L1 and GFAP were directly proportional to hypertension by Spearson / Pearson analysis, and were correlated with sex, age, diabetes, hyperlipidemia and alcohol consumption. There was no correlation between smoking and other factors. The levels of serum UCH-L1 and GFAP were significantly higher than those of the control group (P 0.05), and there was no significant difference in the levels of serum UCH-L1 and GFAP between the two groups at different time of onset (P 0.05). The levels of serum UCH-L1 and GFAP in the severe group were higher than those in the control group (P 0.05). The levels of serum UCH-L1 and GFAP in severe patients were higher than those in mild patients (P 0.05), and there was a significant difference between the levels of serum UCH-L1 and GFAP and infarct size in the observation group. The results of Pearson correlation analysis showed that the expression levels of serum UCH-L1 and GFAP were positively correlated with those of R0.634P0.001. Conclusion: the expression of UCH-L1 and GFAP in the early stage of acute cerebral infarction is significantly increased, which is related to the severity of cerebral infarction, and can provide evidence for early clinical diagnosis and treatment.
【作者单位】：重庆市肿瘤研究所重庆市肿瘤医院重庆市癌症中心;新疆医科大学第二附属医院;
【基金】：国家自然科学基金(U1503222)~~
【分类号】：R743.33

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