老年急性动脉粥样硬化性脑血栓患者外周血同型半胱氨酸的变化及意义

发布时间：2018-06-13 16:41

本文选题：急性动脉粥样硬化性脑血栓 + 同型半胱氨酸　；参考：《中国老年学杂志》2016年13期

【摘要】：目的探讨老年急性动脉粥样硬化(AS)性脑血栓患者外周血同型半胱氨酸(Hcy)的变化及临床意义。方法选取老年急性AS脑血栓患者120例(观察组),同时选取在该院体检的健康人群110例作为对照组,检测各组血Hcy及生化指标,同时采用颈动脉多普勒超声仪测量患者颈总动脉内-中膜厚度(IMT)。结果观察组Hcy、超敏C反应蛋白(hs-CRP)和总胆固醇(TC)水平明显高于对照组(P0.05);观察组120有颈AS(CAS)斑块89例,无CAS斑块31例,有CAS斑块患者Hcy水平明显高于无CAS斑块患者(P0.05);有无CAS斑块患者hs-CRP和TC水平比较无统计学差异(P0.05);重度患者Hcy水平明显高于轻度和中度患者(P0.05);中度患者高于轻度患者(P0.05);Spearman秩相关分析显示,血浆Hcy水平与脑梗死病情程度呈正相关(r=0.362,P0.05);Pearson相关分析显示,患者血浆Hcy水平与IMT呈正相关(r=0.817,P0.05)。结论老年急性AS脑血栓患者外周血Hcy高度表达,其与疾病程度有关,可作为老年急性AS脑血栓患者病情、疗效的监测指标。
[Abstract]:Objective to investigate the changes and clinical significance of homocysteine (Hcy) in peripheral blood of aged patients with acute atherosclerosis (as) cerebral thrombosis. Methods 120 aged patients with acute as cerebral thrombosis (observation group) and 110 healthy people (control group) were selected as control group. Blood Hcy and biochemical indexes were detected in each group. IMT was measured by carotid Doppler ultrasound. Results the levels of HcyH, hypersensitive C-reactive protein hs-CRP and total cholesterol TCC in the observation group were significantly higher than those in the control group (P 0.05), while in the observation group, 89 cases had cervical ASCAS plaques and 31 cases had no CAS plaque. The levels of Hcy in patients with CAS plaques were significantly higher than those in patients without CAS plaque (P0.05A), the levels of hs-CRP and TC in patients with or without CAS plaques were not significantly different (P0.05P), the levels of Hcy in patients with severe plaques were significantly higher than those in patients with mild or moderate CAS (P0.05A); Spearman rank correlation analysis showed that, There was a positive correlation between plasma Hcy level and severity of cerebral infarction. Pearson correlation analysis showed that plasma Hcy level was positively correlated with IMT. Conclusion the high expression of Hcy in peripheral blood of aged patients with acute as cerebral thrombosis is related to the degree of disease. It can be used as a monitoring index for the condition and curative effect of senile patients with acute as cerebral thrombosis.
【作者单位】：西宁市第二人民医院;
【分类号】：R743.32

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