前列地尔对急性心肌梗死后左室重构的影响

发布时间：2018-06-15 06:35

本文选题：前列地尔 + 急性心肌梗死　；参考：《上海大学学报(自然科学版)》2016年03期

【摘要】：探讨前列地尔防治急性心肌梗死后左室重构的临床效果.同期选取2010年6月—2015年12月于同济医院住院治疗的73例急性心肌梗死患者,将患者随机分为常规治疗组和前列地尔治疗组,两组患者均采用冠心病常规治疗方法进行治疗,包括休息、吸氧、调脂、扩冠、双联抗血小板等对症支持治疗.前列地尔组在上述治疗基础上增加前列地尔注射液治疗,10μg前列地尔注射液加入0.9%氯化钠注射液10 m L静脉推注,1次/d.连续治疗7 d.治疗28 d后,常规治疗组左室舒张末期内径(left ventricular end-diastolic dimension,LVDd)、左室收缩末期内径(left ventricular end-systolic dimension,LVDs)、室间隔厚度(interventricular septal thickness,IVST)、左室后壁舒张末期厚度(left ventricular posterior wall end-diastolic,LVPWd)、射血分数(ejection fraction,EF)、E峰/A峰比值较治疗3 d后无显著改善(P0.05);前列地尔组在治疗28 d后与治疗3 d后相比,LVDd,LVDs,E峰/A峰比值有明显减小,EF值明显升高(均达到P0.05),IVST与LVPWd变化不明显.前列地尔在短期内对急性心肌梗死后心功能有改善作用,对左室重构影响不大.
[Abstract]:To investigate the clinical effect of alprostadil on left ventricular remodeling after acute myocardial infarction. From June 2010 to December 2015, 73 patients with acute myocardial infarction were randomly divided into routine treatment group and alprostadil group. These include rest, oxygen inhalation, lipid regulation, crown enlargement, dual anti-platelet therapy and other symptomatic support therapy. In the alprostadil group, 10 渭 g alprostadil injection was added to 0.9% sodium chloride injection 10 mL intravenously for once a day on the basis of the above treatment. Continuous treatment for 7 days. After 28 days of treatment, In routine treatment group, left ventricular end-diastolic dimension, left ventricular end-systolic dimension, interventricular septal thickness, left ventricular posterior wall end-diastolic thickness, left ventricular posterior wall end-diastolic thickness, ejection fraction and ratio of E peak to E peak were not found in routine treatment group. Compared with 3 days after treatment, the ratio of LVDdT / E peak / A peak in alprostadil group was significantly decreased and EF value was significantly increased (P 0.05%, P < 0.05), IVST and LVPWD were not significantly changed. Alprostadil can improve cardiac function after acute myocardial infarction in short term, but has little effect on left ventricular remodeling.
【作者单位】：同济大学医学院附属同济医院心内科;宁波市镇海区人民医院心电图室;
【基金】：国家自然科学基金资助项目(81470515;81270314) 上海市科委医学引导(重点)基金资助项目(134119a3000)
【分类号】：R542.22

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