脓毒血症患者血清白细胞介素-27和C-反应蛋白及降钙素原水平与病情严重程度的关系研究

发布时间：2018-06-17 04:29

本文选题：脓毒血症 + 白细胞介素-　；参考：《中华医院感染学杂志》2017年24期

【摘要】：目的探讨脓毒血症患者血清白细胞介素-27(IL-27)、C-反应蛋白(CRP)和降钙素原(PCT)水平,及血清IL-27、CRP、PCT与脓毒血症预后的关系。方法选择2013年1月-2015年12月医院收治的脓毒血症患者80例作为脓毒血症组,全身炎症反应综合征非脓毒血症患者80例作为对照组;观察分析两组患者血清IL-27、CRP、PCT水平。结果脓毒血症组患者血清IL-27和PCT水平高于对照组(P0.05);IL-27诊断脓毒血症的灵敏度、特异度、阳性预测值、阴性预测值、ROC曲线下面积分别为67.58%、73.12%、62.13%、76.52%、0.753;CRP诊断脓毒血症的灵敏度、特异度、阳性预测值、阴性预测值、ROC曲线下面积分别为54.23%、64.35%、69.87%、53.24%、0.594;PCT诊断脓毒血症的灵敏度、特异度、阳性预测值、阴性预测值、ROC曲线下面积分别为79.03%、76.42%、79.58%、57.41%、0.845;脓毒血症休克患者血清IL-27和PCT水平高于脓毒血症非休克患者(P0.05);脓毒血症死亡患者血清IL-27和PCT水平高于脓毒血症存活患者(P0.05)。结论脓毒血症患者血清IL-27和PCT水平升高,IL-27和PCT在脓毒血症的诊断、严重程度及预后评估中具有一定价值。
[Abstract]:Objective to investigate the serum levels of serum interleukin-27 (IL-27) and procalcitonin (PCT) in patients with sepsis, and the relationship between serum IL-27 and prognosis of sepsis. Methods from January 2013 to December 2015, 80 patients with sepsis were selected as sepsis group and 80 patients with systemic inflammatory response syndrome as control group. Results the serum levels of IL-27 and PCT in the sepsis group were higher than those in the control group (P 0.05). The sensitivity, specificity, positive predictive value and negative predictive value of IL-27 in the diagnosis of sepsis were 67.58 and 73.12 respectively. The positive predictive value, negative predictive value and area under the ROC curve were 54.23 and 64.35, respectively. The sensitivity, specificity, positive predictive value of PCT in diagnosing sepsis were 69.87 and 53.240.594g, respectively. The area under the ROC curve was 79.03 and 76.42, respectively. The serum levels of IL-27 and PCT in septic shock patients were higher than those in septic non-shock patients (P 0.05), and the levels of serum IL-27 and PCT in septic death patients were higher than those in surviving sepsis patients (P 0.05). Conclusion the elevated levels of IL-27 and PCT in patients with sepsis may be valuable in the diagnosis, severity and prognosis of sepsis.
【作者单位】：温州医科大学附属第二医院急诊科;温州医科大学附属第一医院心血管内科;温州医科大学附属黄岩医院急诊科;
【基金】：浙江省医药卫生基金资助项目(2015KYA152)
【分类号】：R459.7

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