不同给药方式对重组人脑利钠肽治疗慢性心力衰竭急性失代偿性重症患者的对比研究

发布时间：2018-06-19 11:06

本文选题：重组人脑利钠肽 + 慢性心力衰竭　；参考：《中国医院药学杂志》2016年18期

【摘要】：目的:对比研究不同给药方式对重组人脑利钠肽(rhBNP)治疗慢性心力衰竭急性失代偿性重症(ADHF)患者的临床疗效。方法:入选ADHF患者62例随机分为2组,A组为rhBNP连续给药治疗组,B组为rhBNP间歇给药治疗组。观察2组治疗前后的临床疗效、心率、平均动脉压、尿量、心功能指标及血浆BNP水平变化。结果:与治疗前比较,治疗后各组心率、平均动脉压、尿量、左心室射血分数、血浆BNP水平、每搏输出量、心脏指数和心肌纵向应变率均得到改善(P0.05或P0.01)。治疗后,rhBNP连续给药治疗组的疗效稍强于rhBNP间歇给药治疗组。A组治疗总有效率与B组相比,无显著性差异(84.4%vs 73.3%)(P0.05),但B组在血流动力学等参数(24 h尿量、心率、平均动脉压、BNP、LVEF、SV、CI)改善方面不亚于A组。结论:rhBNP治疗慢性心力衰竭急性失代偿重症患者疗效显著,可明显改善患者的心衰症状。rhBNP间歇给药的治疗方案也值得临床推广。
[Abstract]:Aim: to compare the clinical effects of different administration methods on recombinant human brain natriuretic peptide (rhBNP) in the treatment of acute decompensated severe ADHFs with chronic heart failure (CHF). Methods: 62 patients with ADHF were randomly divided into two groups: group A: rhBNP continuous treatment group and group B: rhBNP intermittent administration group. The changes of clinical efficacy, heart rate, mean arterial pressure, urine volume, cardiac function and plasma BNP levels were observed before and after treatment. Results: heart rate, mean arterial pressure, urine volume, left ventricular ejection fraction (LVEF), plasma BNP level, cardiac output, cardiac index and myocardial longitudinal strain rate were improved after treatment (P 0.05 or P 0.01). After treatment, the total effective rate of group A was slightly stronger than that of group A. there was no significant difference in total effective rate between group A and group B, but there was no significant difference in total effective rate between group A and group B, but there was no significant difference between group B and group B in terms of hemodynamic parameters, such as 24 h urine volume and heart rate. The improvement of mean arterial pressure (BNP) was no less than that of group A. Conclusion: the treatment of the patients with chronic heart failure with acute decompensation is effective, and the intermittent administration of rhBNP is worth popularizing.
【作者单位】：江阴市人民医院心内科;
【基金】：无锡市科技局科技计划项目(编号:[2012]136号CSZOON1251)
【分类号】：R541.6

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