湿润烧伤膏联合莫匹罗星治疗烧伤残余创面的疗效观察

发布时间：2018-06-24 01:05

本文选题：湿润烧伤膏 + 莫匹罗星　；参考：《中成药》2016年07期

【摘要】：目的观察湿润烧伤膏联合莫匹罗星治疗烧伤残余创面的临床疗效。方法 30例烧伤残余创面患者进行随机、自身对照临床试验。将每例患者的两个残余创面按照随机数字表法分为试验组与对照组,试验组创面使用湿润烧伤膏及莫匹罗星的混合剂外用;对照组创面仅使用莫匹罗星外用。比较两组14 d时的创面愈合率,第3、7、14天使用视觉模拟评分法(VAS)评价创面的疼痛程度,并统计比较两组的创面细菌培养转阴情况。此外,观察治疗过程中患者的不良反应。结果用药后14 d,试验组与对照组创面愈合率分别为(83.2±1.9)%和(72.9±5.2)%,组间比较,差异有统计学意义(P0.05)。组间VAS疼痛评分比较,在第3、7、14天组间比较,差异均有统计学意义(P0.05)。治疗14 d后,试验组及对照组细菌转阴率分别为73%及75%,两组无显著差异(P0.05)。患者在治疗过程中均无不良反应。结论莫匹罗星与湿润烧伤膏联用未发现全身及局部不良反应,该方法能缩短烧伤残余创面的愈合时间,减轻创面疼痛,具有较好的抗感染作用。
[Abstract]:Objective to observe the clinical effect of MEBO combined with mupiroxine in treating residual burn wounds. Methods A randomized, self-controlled clinical trial was conducted in 30 patients with residual burn wounds. Two residual wounds of each patient were randomly divided into two groups: the experimental group and the control group. The experimental group was treated with MEBO and the mixture of mupiroxine, while the control group was only treated with mupiroxine. The wound healing rate at 14 days was compared between the two groups. Visual analogue score (VAS) was used to evaluate the degree of wound pain on the 3rd day and 14th day, and the bacterial culture turned negative in the two groups. In addition, the adverse reactions of patients during treatment were observed. Results on the 14th day after treatment, the wound healing rates of the experimental group and the control group were (83.2 卤1.9)% and (72.9 卤5.2), respectively. The difference between the two groups was statistically significant (P0.05). There were significant differences in VAS pain score between groups on day 3 and day 14 (P0.05). After 14 days treatment, the negative rate of bacteria in the experimental group and the control group was 73% and 75%, respectively. There was no significant difference between the two groups (P0.05). There were no adverse reactions in the course of treatment. Conclusion the combination of mupiroxine and MEBO has not found any systemic or local adverse reactions. This method can shorten the healing time of residual burn wounds and relieve wound pain. It has a good anti-infection effect.
【作者单位】：扬州大学临床医学院;
【分类号】：R644

【参考文献】