颅脑损伤后垂体功能低下发生的影响因素及意义

发布时间：2018-06-26 03:01

本文选题：脑创伤 + 内分泌功能　；参考：《广东医学》2017年01期

【摘要】：目的探讨颅脑损伤后垂体功能低下发生的影响因素及其临床意义。方法记录并分析112例颅脑损伤患者的内分泌情况、急性期并发症和伤后1年症状。结果颅脑损伤后第1天部分患者开始出现垂体功能低下,第3天垂体功能低下发生情况最为严重,从第7天开始逐渐恢复。颅底骨折、弥散性轴索损伤、中线移位1cm是发生内分泌功能低下的影响因素(P0.05),垂体功能低下患者急性期肺炎的发生率高于垂体功能正常患者,差异有统计学意义(P0.05)。伤后1年垂体功能低下患者头晕、焦虑、肥胖症状发生率高于垂体功能正常患者,差异有统计学意义(P0.05)。结论垂体功能低下是颅脑损伤患者常见的并发症,需要对颅脑损伤患者常规进行内分泌功能检查,并且进行长期的随访。
[Abstract]:Objective to investigate the influence factors and clinical significance of hypophysis dysfunction after craniocerebral injury. Methods the endocrine, acute complications and 1 years after injury were recorded and analyzed in 112 patients with craniocerebral injury. Results in first days after craniocerebral injury, some patients began to appear hypophyseal dysfunction, and the occurrence of pituitary hypofunction at third days was the most important. To be serious, gradually recover from seventh days. Skull base fracture, diffuse axonal injury, midline displaced 1cm are the influential factors of endocrine dysfunction (P0.05). The incidence of acute pneumonia in patients with hypophyseal dysfunction is higher than that of normal pituitary function patients, the difference has statistical significance (P0.05). 1 years after injury, the patients with hypophysis function are dizzy, The incidence of anxiety and obesity is higher than that of normal pituitary function patients, the difference is statistically significant (P0.05). Conclusion hypopituitarism is a common complication of patients with craniocerebral injury. It is necessary to conduct routine endocrine function examination for patients with craniocerebral injury and follow up for a long time.
【作者单位】：南方医科大学南方医院神经外科;
【基金】：广东省科技计划项目(编号:2013B021800304) 南方医科大学南方医院院长基金项目(编号:2013B017)
【分类号】：R651.15

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