颅脑外科手术患者术中预防使用抗菌药物追加时机与次数研究

发布时间：2018-06-28 17:40

本文选题：颅脑 + 外科　；参考：《中华医院感染学杂志》2016年18期

【摘要】：目的研究颅脑外科手术患者术中预防使用抗菌药物追加时机和次数,促进临床围手术期合理给药,预防切口感染可能。方法结合实例,以药动学模型为基础,以fTMIC%达到100.0%为目标阈值,结合抗菌药物的有效覆盖时间确定术中追加时机和追加次数。结果颅脑外科手术患者术中抗菌药物的追加时机应以上一剂抗菌药物的浓度下降至MIC的时间点为准,以此类推,根据术前用药时机、手术历时及术后4h的整个时间段确定术中(后)追加次数。结论依据抗菌药物的PK/PD特性从理论上探讨了颅脑外科手术围手术期术中追加时机和追加次数的问题,可初步指导术中追加时机和追加次数的合理制定。
[Abstract]:Objective to study the timing and times of prophylactic use of antimicrobial agents in patients undergoing craniocerebral surgery, to promote rational administration of antibiotics in clinical perioperative period, and to prevent the possibility of incision infection. Methods based on the pharmacokinetic model, the target threshold of fTMIC% was 100.0% and the effective coverage time of antimicrobial agents was used to determine the time and times of intraoperative supplementation. Results the additional time of antimicrobial agents in patients undergoing craniocerebral surgery should be reduced to the time point of MIC, and so on, according to the time of medication before operation. The duration of operation and the whole time period of 4 h after operation were determined. Conclusion according to the PKP / PD characteristics of antimicrobial agents, this paper theoretically discusses the issue of the time and times of supplementary during the perioperative period of craniocerebral surgery, which can be used to guide the rational formulation of the timing and times of intraoperative supplementation.
【作者单位】：湖南省肿瘤医院药学部;
【基金】：湖南省卫生计生委科研基金资助项目(c2015-49)
【分类号】：R651.15

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