血必净注射液治疗老年系统性炎症反应综合征的临床疗效及对血清炎性因子的影响

发布时间：2018-06-29 12:06

本文选题：系统性炎症反应综合征 + 血必净注射液　；参考：《中国老年学杂志》2017年13期

【摘要】：目的探讨血必净注射液治疗老年系统性炎症反应综合征(SIRS)的临床疗效及其对患者血清炎症因子水平的影响。方法老年SIRS危重患者80例,依据均衡设计数据表法随机分为观察组和对照组各40例,对照组给予常规抗生素及补液治疗,观察组在对照组的基础上辅以血必净氯化钠注射液静脉点滴治疗,对治疗前及治疗3、5、7 d患者体温(T)、心率(HR)、呼吸频率(RR)、血白细胞(WBC)、治疗后血清C反应蛋白(CRP)及血清炎症因子[肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-10]等指标进行检测。结果观察组T、RR、HR等指标在治疗第3天均显著改善,优于对照组(P0.05),第5、7天HR水平明显下降(P0.01);治疗后WBC及CRP水平较治疗前均显著下降,且观察组显著低于对照组(P0.01);治疗后TNF-α、IL-6、IL-10水平显著优于治疗前,且观察组TNF-α、IL-6下降水平显著高于对照组,IL-10水平显著高于对照组(均P0.05)。结论血必净注射液治疗SIRS的作用机制可能与拮抗炎性介质、降低血清内炎症因子水平、增强抑炎因子释放等因素有关。
[Abstract]:Objective to investigate the clinical effect of Xuebijing injection in the treatment of senile systemic inflammatory response syndrome (Sirs) and its effect on serum inflammatory factor level. Methods 80 elderly patients with Sirs were randomly divided into two groups: observation group (n = 40) and control group (n = 40). The observation group was treated by intravenous drip of Xuebijing sodium chloride injection on the basis of the control group. Body temperature (T), heart rate (HR), respiratory rate (RR), white blood cell (WBC), serum C-reactive protein (CRP) and inflammatory factor (TNF- 伪, IL-6 IL-10) were measured before and after treatment. Results on the 3rd day after treatment, the indexes of RRN HR in the observation group were significantly improved, which were better than those in the control group (P0.05), and the level of HR decreased significantly (P0.01) on the 5th day (P0.01), the levels of WBC and CRP decreased significantly after treatment, and the levels of WBC and CRP decreased significantly in the observation group on the 3rd day after treatment. The level of TNF- 伪 IL-6 IL-10 in the observation group was significantly lower than that in the control group (P0.01), and the decrease of TNF- 伪 IL-6 in the observation group was significantly higher than that in the control group (P0.05). Conclusion the mechanism of Xuebijing injection in the treatment of Sirs may be related to the antagonism of inflammatory mediators, the reduction of the level of inflammatory factors in serum and the enhancement of the release of anti-inflammatory factors.
【作者单位】：重庆市人民医院普外科;重庆市人民医院麻醉科;重庆市人民医院重症医学科;重庆市人民医院妇产科;
【分类号】：R459.7

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