非对称性二甲基精氨酸在脑梗死患者急性期的表达

发布时间：2018-07-05 14:40

本文选题：脑梗死 + 急性　；参考：《中国脑血管病杂志》2016年05期

【摘要】：目的探讨血浆非对称性二甲基精氨酸(ADMA)在脑梗死患者急性期的表达及脑梗死危险因素分析。方法回顾性纳入2013年3月至2015年8月于西安医学院第一附属医院神经内科住院的100例脑梗死急性期患者为脑梗死组,依据美国国立卫生研究院卒中量表(NIHSS)评分,分为轻型梗死组(4分,21例)、中型梗死组(4~15分,49例)、重型梗死组(15分,30例);同期体检无脑血管疾病者100例作为对照组。采用酶联免疫吸附法检测血浆ADMA浓度,比较各组间血浆ADMA水平。结果急性脑梗死轻、中、重型3个组及对照组血浆ADMA水平分别为(0.80±0.16)、(1.14±0.28)、(1.33±0.33)、(0.52±0.16)μmol/L,组间比较,差异有统计学意义(F=2.32,P0.05)。经多因素Logistic回归分析后,提示高ADMA水平是脑梗死急性期的独立危险因素(OR=1.140,95%CI:1.078~1.212,P=0.045)。结论血浆ADMA水平在轻、中、重型脑梗死患者中表达逐渐升高,ADMA水平越高,神经功能缺损越严重。ADMA可能是脑梗死急性期的独立危险因素。
[Abstract]:Objective to investigate the expression of plasma asymmetric dimethyl arginine (ADMA) in patients with acute cerebral infarction and the risk factors of cerebral infarction. Methods from March 2013 to August 2015, 100 patients with acute cerebral infarction who were admitted to Department of Neurology, first affiliated Hospital of Xi'an Medical College, were included as cerebral infarction group. According to the National Institutes of Health Stroke scale (NIHSS) score. The patients were divided into mild infarction group (n = 21), moderate infarction group (n = 49) and severe infarction group (n = 30). The plasma ADMA levels were measured by Elisa and the plasma ADMA levels were compared. Results the plasma levels of ADMA in mild, moderate, severe and control groups were (0.80 卤0.16), (, 1.14 卤0.28), (, 1.33 卤0.33), (, 0.52 卤0.16) 渭 mol / L, respectively (P 0.05). Multivariate logistic regression analysis showed that high ADMA level was an independent risk factor in acute cerebral infarction (OR 1.140? 95 CI: 1.0781.212P0. 045). Conclusion the higher the level of ADMA in patients with mild, moderate and severe cerebral infarction is, the more serious the neurological deficit is. ADMA may be an independent risk factor in acute stage of cerebral infarction.
【作者单位】：西安医学院第一附属医院神经内科;
【基金】：陕西省自然科学基金资助项目(2010JM4054) 陕西省教育厅科研基金资助项目(14JK1629) 陕西省卫生厅科研基金资助项目(2010H27) 西安医学院第一附属医院基金(XYFY2013-09)
【分类号】：R743.33

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