血小板与淋巴细胞比值和急性脑梗死患者颈动脉粥样硬化斑块稳定性的关系

发布时间：2018-07-12 15:17

本文选题：血小板 + 淋巴细胞　；参考：《中风与神经疾病杂志》2017年09期

【摘要】：目的探讨血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)和急性脑梗死患者颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色多普勒超声仪检查结果,将184例急性脑梗死患者分为稳定斑块组64例,不稳定斑块组120例,及70例正常对照组。收集一般临床资料及缺血性脑血管病危险因素,测定白细胞计数、红细胞计数、中性粒细胞数、血脂、肌酐、尿酸等并进行比较。结果 (1)与对照组相比,急性脑梗死组PLT、TC、TG、LDL-C、尿酸、纤维蛋白原、PLR、空腹血糖明显增高,差异具有统计学意义(P0.05);(2)不稳定斑块组与对照组相比PLR水平明显升高,具有显著性差异(P0.05)。不稳定组PLR明显高于稳定斑块组,具有显著统计学差异(P0.05)。(3)调整性别、年龄因素后,PLR为颈动脉不稳定斑块的危险因素(OR=1.505,95%CI0.995~1.003,P=0.0010.05)。结论 PLR的增高和颈动脉粥样硬化斑块的不稳定性密切相关。
[Abstract]:Objective to investigate the relationship between platelet / lymphocyte ratio (platelet to lymphocyte / PLR) and carotid atherosclerotic plaque stability in patients with acute cerebral infarction. Methods 184 patients with acute cerebral infarction were divided into stable plaque group (n = 64), unstable plaque group (n = 120) and normal control group (n = 70). General clinical data and risk factors of ischemic cerebrovascular disease were collected and compared with white blood cell count, red blood cell count, neutrophil count, blood lipid, creatinine, uric acid and so on. Results (1) compared with the control group, the levels of LDL-C, uric acid, fibrinogen and fasting blood glucose in the acute cerebral infarction group were significantly higher than those in the control group (P0.05). The level of); (in the unstable plaque group was significantly higher than that in the control group (P0.05). The). (of unstable group was significantly higher than that of stable plaque group (P0.05). (3), and the age factor was the risk factor of unstable plaque of carotid artery (OR 1.50595 CI 0.9951.003Pu 0.0010.05). Conclusion the increase of PLR is closely related to the instability of carotid atherosclerotic plaque.
【作者单位】：中国医科大学附属第四医院神经内科;
【分类号】：R743.33

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