血栓抽吸联合GPI在急性STEMI患者直接PCI中临床疗效的Meta分析

发布时间：2018-07-13 16:58

【摘要】：目的评价血栓抽吸联合血小板糖蛋白ⅡbⅢEIa受体拮抗剂(GPI)在急性STEMI患者直接PCI中的临床疗效。方法计算机检索The Cochrane Library、PubMed、EMbase、CNKI、万方数据库、维普数据库等关于急性STEMI患者直接PCI中应用血栓抽吸联合GPI的随机对照试验,按纳入与排除标准独立选择试验、资料提取和质量评价,对同质研究采用RevMan 5.2软件进行Meta分析。结果最终纳入10项研究,共1223例患者,分为试验组与对照组。Meta分析结果显示：与对照组相比,试验组主要心血管不良事件发生率(OR=0.55,95%CI:0.35-0.88,P=0.01)和无复流/慢血流发生率(OR=0.20,95%CI:0.07-0.62,P=0.005)明显降低；TIMI 3级血流(OR=4.01, 95%CI:2.55-6.32,P0.00001)及ST段回落情况(OR=2.55,95%CI:1.89-3.44,P0.00001)得到明显改善；试验组左室射血分数(OR=7.22,95%CI: 6.03-8.42,P0.00001)和校正的TIMI计帧数(OR=-11.44,95%CI:-13.48--9.40,P0.00001)均优于对照组。结论血栓抽吸联合GPI的应用可以明显降低急性STEMI患者MACE发生率,增加TIMI 3级血流,改善术后ST段回落情况及左室射血分数,降低无复流/慢血流发生率和CTFC数值。
[Abstract]:Objective to evaluate the clinical efficacy of thrombus aspiration combined with platelet glycoprotein II B III EIa receptor antagonist (GPI) in direct PCI of patients with acute STEMI. Methods a computer retrieval of The Cochrane Library, PubMed, EMbase, CNKI, Wanfang database, VP database, and so on, a randomized control of thrombus aspiration combined with thrombus aspiration in acute STEMI patients According to the independent selection test, data extraction and quality evaluation according to the inclusion and exclusion criteria, Meta analysis was carried out by RevMan 5.2 software for homogeneity study. The results were included in the final 10 studies, and 1223 patients were divided into the test group and the control group,.Meta analysis showed that compared with the control group, the incidence of major adverse events of cardiovascular events was compared with the control group (OR =0.55,95%CI:0.35-0.88, P=0.01) and no reflow / slow flow rate (OR=0.20,95%CI:0.07-0.62, P=0.005) were significantly reduced; TIMI 3 blood flow (OR=4.01, 95%CI:2.55-6.32, P0.00001) and ST segment decline (OR=2.55,95%CI:1.89-3.44, P0.00001) were significantly improved; experimental group left ventricular ejection fraction (OR=7.22,95%CI:) and The corrected number of TIMI frames (OR=-11.44,95%CI:-13.48--9.40, P0.00001) were superior to those of the control group. Conclusion the application of thrombus aspiration combined with GPI can obviously reduce the incidence of MACE in acute STEMI patients, increase the blood flow of TIMI 3, improve the decline of ST segment and left ventricular ejection fraction, lower the incidence of no reflow / slow blood flow and CTFC values.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R542.22

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