乌司他丁对急性呼吸窘迫综合征患者炎症反应及细胞免疫功能的影响

发布时间：2018-07-24 08:01

【摘要】：目的:观察乌司他丁(UTI)对急性呼吸窘迫综合征(ARDS)患者疗效、炎症因子及细胞免疫状态的影响。方法:将96例ARDS患者随机分为两组:对照组(48例)给予常规治疗;UTI组(48例)在对照组治疗的基础上应用UTI。比较两组患者治疗前后氧合指数、生命体征、炎症因子及T淋巴细胞亚群的变化,并记录两组患者的机械通气时间、ICU治疗时间及ICU内死亡率。结果:治疗7 d后,UTI组患者的生命体征(RF、HR、MAP)、炎症因子(TNF-a、IL-6、IL-8、PCT、CRP、WBC)、肝功能(AST、ALT)、肾功能(BUN、Cr)及APACHEⅡ评分、MODS评分均低于对照组(P0.05或P0.01),氧合指数(PaO_2/FiO_2)及细胞免疫(CD4~+、CD4~+/CD8~+)均高于对照组(P0.01)。UTI组患者的机械通气时间、ICU治疗时间短于对照组(均P0.05),UTI组患者的ICU内死亡率低于对照组(P0.05)。两组患者不良反应发生率差异无统计学意义(P0.05)。结论:UTI用于ARDS能更有效地改善氧代谢和生命体征,改善肝肾功能,降低APACHEⅡ评分、MODS评分,缩短机械通气时间、ICU治疗时间,降低ICU内死亡率,其机制可能与UTI清除体内炎症因子和调节细胞免疫功能有关。
[Abstract]:Aim: to observe the effects of ulinastatin (UTI) on the efficacy, inflammatory factors and cellular immunity of patients with acute respiratory distress syndrome (ARDS). Methods: 96 patients with ARDS were randomly divided into two groups: the control group (n = 48) received routine treatment and the control group (n = 48) were treated with UTI on the basis of the control group. The changes of oxygenation index, vital signs, inflammatory factors and T lymphocyte subsets were compared between the two groups before and after treatment, and the time of mechanical ventilation and the mortality in ICU were recorded. Results: after 7 days of treatment, the vital signs (RFHRMAP), inflammatory factors (TNF-aIL-6 / IL-8), liver function (ASTnalt), renal function (Buchr) and APACHE 鈪，

本文编号：2140740