早期脑钠肽、C反应蛋白、乳酸水平联合检查评估老年感染性休克患者预后的临床价值

发布时间：2018-07-26 19:02

【摘要】：目的探讨早期脑钠肽(BNP)、C反应蛋白(CRP)、乳酸(Las)水平联合检查评估老年感染性休克患者预后的临床价值。方法回顾性分析2012年6月至2015年3月该院重症监护室(ICU)治疗的75例老年感染性休克患者的临床资料,依据28 d后的存活情况分为存活组(41例)和死亡组(34例),分析不同组别BNP、CRP、Las的差异,并采用受试者工作曲线(ROC)进一步分析。结果死亡组BNP、CRP、Las水平均高于生存组(P0.05);约登指数(Youden)最大原则确定BNP、CRP、Las评估最佳临界值为:13 310.47 pg/ml、23 mg/L、3.1 mmol/L,此时评估"死亡"的灵敏度、特异度、准确率分别为:82.35%、78.05%、80.00%;67.64%、70.73%、69.33%;79.41%、87.80%、84.00%。三种指标联合评估时,≥1种、≥2种、3种高于临界值的灵敏度、特异度、准确率分别为:97.06%、43.90%、68.00%;88.24%、85.37%、86.67%;58.82%、95.12%、78.67%。结论早期联合检测BNP、CRP、Las有助于评估老年感染性休克患者预后,这3种中任意≥2种高于临界值时多提示预后不佳。
[Abstract]:Objective to evaluate the clinical value of early brain natriuretic peptide (BNP) (BNP) C-reactive protein (CRP),) lactate (Las) level in evaluating the prognosis of elderly patients with septic shock. Methods the clinical data of 75 elderly patients with septic shock treated by (ICU) from June 2012 to March 2015 were retrospectively analyzed. According to the survival condition after 28 days, the patients were divided into survival group (41 cases) and death group (34 cases). Results the level of BNP-CRP Las in death group was higher than that in survival group (P0.05), and the critical value of BNP-CRP Las was 13 310.47 mg / ml ~ (23 mg / L) / L ~ 3.1 mmol 路L ~ (-1). The sensitivity, specificity and accuracy of "death" were evaluated as follows: the sensitivity, specificity and accuracy of "death" were 87.3578.05 / 80.0077.6470.730.79.3379.41and 87.804.00 respectively. The sensitivity, specificity, and accuracy of 鈮，

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