脓毒症患者血小板微粒与微RNA-155水平的变化规律及意义

发布时间：2018-08-05 12:04

【摘要】：目的探讨血小板微粒(PMPs)和微RNA(miRNA)-155与脓毒症患者病情和预后的关系。方法选择脓毒症患者61例,根据28d预后将其分为存活组和死亡组;根据病情严重程度将其分为脓毒症组、严重脓毒症组及脓毒症休克组。比较各组患者APACHEⅡ评分,使用流式细胞仪进行PMPs定量,利用实时荧光定量PCR检测患者血浆miRNA-155水平。Spearman相关性分析确认PMPs水平、miRNA-155水平与患者APACHEⅡ评分的关系。结果与存活组比较,死亡组患者PMPs水平较高(P0.05)。脓毒症、严重脓毒症、脓毒症休克3组患者的PMPs水平比较,差异均有统计学意义(P0.05)。死亡组患者的miRNA-155水平相对于存活组提高(P0.05),严重脓毒症组及脓毒症休克组患者的miRNA水平较脓毒症组明显提高(P0.05)。患者PMPs水平及miRNA-155水平均与APACHEⅡ评分呈正相关,同时患者PMPs水平与microRNA-155水平也呈正相关。PMPs水平联合miRNA-155水平预测脓毒症患者死亡的ROC曲线下面积达0.831。结论脓毒症患者的PMPs水平及miRNA-155水平与脓毒症患者的病情及预后有关,miRNA-155可能引起脓毒症患者的PMPs水平增高。
[Abstract]:Objective to investigate the relationship between platelet microparticle (PMPs) and microRNA (miRNA)-155 in patients with sepsis. Methods Sixty-one patients with sepsis were divided into survival group and death group according to the prognosis of 28 days, sepsis group, severe sepsis group and septic shock group according to the severity of the disease. APACHE 鈪，

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